Effect of Glycemic Control on Adipokines in Diabetic Patients with Pulmonary Hypertension | ||
| The Medical Journal of Cairo University | ||
| Article 106, Volume 87, March, March 2019, Pages 871-876 PDF (562.79 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjcu.2019.52636 | ||
| Authors | ||
| MANAR M. EL-ZAKI, M.D.; NADER KANDIL, M.D.; SAMIA HUSSEIN, M.D.; MAI M. HASAN, M.D.; ABEER A. SAEED, M.D. | ||
| The Departments of Cardiology*, Medical Biochemistry & Molecular Biology** and Medical Physiology***, Faculty of Medicine, Zagazig University, Egypt | ||
| Abstract | ||
| Abstract Background: Recent studies suggested a role of diabetes in regulating the outcome of pulmonary hypertension. Several cytokines are dysregulated in pulmonary hypertension, and were considered accurate predictors of the prognosis. Aim of Study: To evaluate the effects of glycemic control on hemodynamics, metabolic and adipokines (leptin, apelin and adiponectin) levels in patients with pulmonary hyperten-sion and diabetes. Subjects and Methods: Thirty-five pulmonary hypertension patients with diabetes assigned into two groups according to glycosylated hemoglobin (HbA1c) level; tightly controlled group (Group I) (n=20) and conventionally controlled group (Group II) (n=15). Demographic characteristics, hemodynamic assessment, metabolic and serum adipokines levels were assesed. Results: Both groups showed insignificant difference in age, BMI and left ventricular ejection fraction; while mean pulmonary arterial pressure, HbA1c, fasting blood glucose, insulin, HOMA-IR, Cholesterol, triglycerides, Interleukin-6, leptin and apelin were significantly decreased in group I. IL-6, leptin and apelin have significant positive correlation with glucose, insulin, HOMA-IR, Cholesterol, TG and MPAP in both groups. Conclusion: Good glycemic control has an impact on hemodynamics, metabolic, inflammatory and adipokine pattern in diabetic patients with pulmonary hypertension, which may affect the progression of the disease. | ||
| Keywords | ||
| diabetes; leptin; Apelin; adiponectin; IL6; pulmonary hypertension | ||
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