VITAMIN D STATUS IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA | ||
| Zagazig University Medical Journal | ||
| Article 20, Volume 25, Issue 6, November 2019, Pages 960-966 PDF (121.1 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2019.10577.11140 | ||
| Authors | ||
| Laila Sherief; Mohammed Beshir; Nermin Raafat; Heba Magdy Elsayed | ||
| Abstract | ||
| Background: Skeletal morbidities are a common initial presentation and outcome in acute lymphoblastic leukemia(ALL). Vitamin D plays a vital role in the physiological regulation of calcium and phosphate transport and bone mineralization. Also high (25(OH)) level and high vitamin d intake at the time of diagnosis and initiation of anticancer treatment were associated with improved outcome. Methods: Twenty five ALL patients admitted to hematology and oncology unit, children hospital Zagazig University in one-year .vitamin D (25 (OH)) level was assessed in all patients at diagnosis. Patients were classified into deficient vitamin D (0-20)ng/ml , insufficient vitamin D (20-30)ng/ml and sufficient vitamin D (30-50)ng/ml. Statistical analysis was done to determine relation between different groups and ALL patients characteristics. Results: Vitamin D deficient in 24% of patients, vitamin D insufficient in 48% of patients, and vitamin D sufficient in 28% of patients. There was high statistical difference between different groups regarding bone pain and sex. Conclusions: A non-sufficient level in childhood all (deficiency and insufficiency) is common in childhood ALL and this is related to bone pain as initial clinical presentation. Vitamin D is related to presentation and prognosis of ALL in children. | ||
| Keywords | ||
| Acute lymphoblastic leukemia; Vitamin D, Bone pain | ||
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