The Correlation between Macular Ischemia by Fundus Fluorescein Angiography and Spectral Domain Optical Coherence Tomography Findings in Diabetic Macular Edema | ||
| The Medical Journal of Cairo University | ||
| Article 17, Volume 86, June, June 2018, Pages 1213-1219 PDF (613.99 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjcu.2018.56275 | ||
| Authors | ||
| DINA T. ABDEL-SALAM, M.Sc.; AHMED DAHAB, M.D.; ADEL FATHY, M.D.; KARIM RAAFAT, M.D. | ||
| The Department of Ophthalmology, Faculty of Medicine, Cairo University | ||
| Abstract | ||
| Abstract Background: To study the association between the OCT structural changes, and vascular changes around the fovea in FFA in the detection of ischemic diabetic maculopathy. Material and Methods: A 35 eyes of 25 patients with ischemic and mixed diabetic maculopathy were included as determined by irregular margins of the FAZ in fluorescein angiography. We measured the best-corrected visual acuity (BCVA), central macular thickness, inner retinal layer thickness and the lateral extent of inner segment-outer segment (IS-OS) disruption on SD-OCT images, as well as the FAZ to optic nerve head (FAZ/ONH) area ratio using the Image J program. Results: The central macular thickness and the inner retinal layer thickness showed no significant correlation with FAZ/ONH area ratio (p=0.161, 0.480 respectively). The mean horizontal and vertical extents of IS-OS disruption were not significantly correlated with FAZ/ONH area ratio (p=0.630 and p=0.732 respectively. The horizontal and vertical extents of IS-OS disruption showed a significant correlation with Log MAR BCVA (r=0.798 and 0.795 respectively, p<0.001 in both). The FAZ/ONH area ratio was positively correlated with LogMAR BCVA but was not statistically significant (p=0.815, r=–0.041). Conclusion: In patients with diabetic retinopathy, it is not possible to predict FAZ area based solely on the measure-ments assessing volume and thickness or retinal structure evaluation on OCT. Consequently, at present OCT cannot replace FA in the detection of ischemic or mixed diabetic maculopathy. | ||
| Keywords | ||
| Diabetic macular edema– Optical coherence tomography –Fundus Fluorescein Angiography | ||
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