The Value of Using Amantadine Upon Improving Conscious Level in Isolated Head Trauma Patients Guided by Glasgow Coma Scale and Bispectral Index | ||
| The Medical Journal of Cairo University | ||
| Article 102, Volume 86, June, June 2018, Pages 1917-1925 PDF (470.53 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjcu.2018.56758 | ||
| Authors | ||
| AHMED S. SAAD, M.Sc.; OMAR WAGIH, M.D.; INAS ELSHAZLY, M.D.; HISHAM ABU ELDAHAB, M.D.; SAFINAZ OSMAN, M.D. | ||
| The Department ofAnaesthesiology, Faculty of Medicine, Cairo University | ||
| Abstract | ||
| Abstract Background: We performed the current study to find out the effect of Amantadine upon rate of improvement of con-scious level in patients with isolated head injuries undergoing surgical intervention. Aim of the Study: Finding out the value of using Amanta-dine upon improving of consciousness in head trauma patients. Patients and Methods: Patients in group 1 (n=20) were given amantadine intraoperative at a dose of 100mg IV infusion over 3 hours, then amantadine were given at a dose of 100mg IV infusion over 3 hours every 12 hours for 7 days then was switched to tablet form at a dose of 300mg per day divided into 3 equal doses, the 1st was given in the morning and the last before 5 o'clock PM. Patients in group 2 (n=20) were given placebo instead at the same form and intervals. Glasgow coma scale and bispectral index readings were recorded at time of arrival, immediate post operative, 3 days and 2 weeks post operative. Results: We found that Glasgow coma scale rate of im-provement in group 1 was 4.53±2.61 and in group 2 was 2.11 ±2.81 which is statistically significant p-value 0.014. Conclusion: We conclude from this study that the rate of improvement of patients given amantadine was significantly higher than those given placebo. | ||
| Keywords | ||
| Amantadine – Glasgow coma scale – Bispectral index | ||
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