Osman, A., Toliba, A. (2019). Hepatoprotective Effects of Crude Phenolic-rich Extract from Oyster Mushroom (Pleurotus ostreatus). test, 47(2), 157-164. doi: 10.21608/ejfs.2019.16213.1017
Ali Osman; Abbas Omar Toliba. "Hepatoprotective Effects of Crude Phenolic-rich Extract from Oyster Mushroom (Pleurotus ostreatus)". test, 47, 2, 2019, 157-164. doi: 10.21608/ejfs.2019.16213.1017
Osman, A., Toliba, A. (2019). 'Hepatoprotective Effects of Crude Phenolic-rich Extract from Oyster Mushroom (Pleurotus ostreatus)', test, 47(2), pp. 157-164. doi: 10.21608/ejfs.2019.16213.1017
Osman, A., Toliba, A. Hepatoprotective Effects of Crude Phenolic-rich Extract from Oyster Mushroom (Pleurotus ostreatus). test, 2019; 47(2): 157-164. doi: 10.21608/ejfs.2019.16213.1017

Hepatoprotective Effects of Crude Phenolic-rich Extract from Oyster Mushroom (Pleurotus ostreatus)

Egyptian Journal of Food Science
Article 13, Volume 47, Issue 2, 2019, Pages 157-164    PDF (1.13 M)
Document Type: Original Article
DOI: 10.21608/ejfs.2019.16213.1017
Authors
Ali Osman1; Abbas Omar Toliba* 2
1Biochemistry Department, Faculty of Agriculture, Zagazig University, 44511, Zagazig, Egypt
2Food sci. Dept., Fac. Agric., Zagazig Univ., Zagazig., Egypt.
Abstract
In this study the hepatoprotective activity of the crude phenolic rich extract (CPRE) isolated from oyster mushrooms on carbon tetrachloride (CCl4)-induced oxidative stress was investigated in albino rats. The hepatoprotective activity was examined through various biochemical parameters. Administration of CCl4 for 28 days exhibited a significant increase (P<0.05) in serum markers of liver damage, i.e., alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, urea, creatinine, total lipids and triglycerides. Whereas, the serum markers were significantly decreased (P<0.05) by CPRE administration. CCl4 exposure significantly decreased (P<0.05) the hepatic antioxidant enzyme activities such as superoxide dismutase and glutathione peroxidase. Contrarily, the CPRE treatments showed significant increases (P<0.05) in these hepatic activities. The results obtained from this study clearly validated the potential antioxidant activity of CPRE isolated from oyster mushrooms against several oxidation systems in-vivo, which contributed to its hepatoprotective effects in CCl4-induced liver injury in male albino rats. Finally, oyster mushrooms could be added as an additional nutrient to food products as it constitutes a new potential source of natural antioxidant and antibacterial agents.
Keywords
Oyster mushrooms; Pleurotus ostreatus; Phenolic compounds; CCl4; Hepatoprotective; Oxidative Stress
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