HISTOPATIIOLOGICAL STUDY OF TIIE EFFECT OF ANTIR,HEUMATIC DR,UGS ON THE GASTR,ODUODENAL MUOOSA | ||
| The Egyptian Journal of Anatomy | ||
| Article 3, Volume 2, Issue 1, January 1979, Pages 19-26 PDF (725.35 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejana.1979.5727 | ||
| Authors | ||
| E. EL.SERAFY; M. TEAF; N' AC'GOUR | ||
| M&nsoura Facutty ol Medicine and,'rNational Eesearclt centre | ||
| Abstract | ||
| The extensive use of antirheuma' tic drugs nowadaYs and their association with many gastrointestinal troubles stimulated the authors to study the histopathological changes which might affect the stomach and duodenum as a result of the administration of these drugs. The occurrence of PePtic ulcers was reported in man after the administration of endomethacin orally (Kamal and Ahmed, 1967; Gramajo and Salomane, 1976 and Loni and Ambrogi, 1968) and in the form of suppositories (Taylor et aI, 1968). Peptie ulcers were also produced in experimental animals when endo' methacin was given by injection (Djahanguiri, 1969). Phenylbutazone was also rePorted to cause erosive gastritis and ulceration in man and animals, Particularly on the greater curvatute, ind malignancy was suspected in the ulcers (Kirsner and Ford, 1955; Kern, ef al 195? and Kowalezuke, 1969). Lyle (19?4) reported the occurrence of bleeding peptic ulcers in patients receiving penicillamine. Chabot et aI (1974) noted the aPpearance of gastritis, gastroduo' denal ulcers and melaena in Pati' ents receiving ketoprofene. The aim of the present work is to further our knowledge about the histopathological effect of antirheumatic drugs on the gastroduodenal mucosa. | ||
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