Elsayed, M., Elsayed, N., Riad, S., Mahmoud, S. (2019). ESTIMATION OF SALIVARY TUMOR NECROISIS FACTOR-ALPHA LEVEL IN PATIENTS WITH EROSIVE ORAL LICHEN PLANUS (A CASE CONTROL STUDY). test, 44(1), 52-56. doi: 10.21608/adjalexu.2019.57576
Mona N Elsayed; Naguiba M Elsayed; Sahar E Riad; Sabah A Mahmoud. "ESTIMATION OF SALIVARY TUMOR NECROISIS FACTOR-ALPHA LEVEL IN PATIENTS WITH EROSIVE ORAL LICHEN PLANUS (A CASE CONTROL STUDY)". test, 44, 1, 2019, 52-56. doi: 10.21608/adjalexu.2019.57576
Elsayed, M., Elsayed, N., Riad, S., Mahmoud, S. (2019). 'ESTIMATION OF SALIVARY TUMOR NECROISIS FACTOR-ALPHA LEVEL IN PATIENTS WITH EROSIVE ORAL LICHEN PLANUS (A CASE CONTROL STUDY)', test, 44(1), pp. 52-56. doi: 10.21608/adjalexu.2019.57576
Elsayed, M., Elsayed, N., Riad, S., Mahmoud, S. ESTIMATION OF SALIVARY TUMOR NECROISIS FACTOR-ALPHA LEVEL IN PATIENTS WITH EROSIVE ORAL LICHEN PLANUS (A CASE CONTROL STUDY). test, 2019; 44(1): 52-56. doi: 10.21608/adjalexu.2019.57576

ESTIMATION OF SALIVARY TUMOR NECROISIS FACTOR-ALPHA LEVEL IN PATIENTS WITH EROSIVE ORAL LICHEN PLANUS (A CASE CONTROL STUDY)

Alexandria Dental Journal
Article 9, Volume 44, Issue 1, April 2019, Pages 52-56    PDF (899.76 K)
Document Type: Original Article
DOI: 10.21608/adjalexu.2019.57576
Authors
Mona N Elsayed* 1; Naguiba M Elsayed2; Sahar E Riad3; Sabah A Mahmoud4
1B.D.S (2003). Department of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry, Alexandria University.
2Professor at Department of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry, Alexandria University.
3Professor at Department of Oral Pathology, Faculty of Dentistry, Alexandria University.
4- Professor and Head of Department of Biochemistry, Faculty of Medicine, Alexandria University.
Abstract
INTRODUCTION: Oral lichen planus (OLP) is a relatively common chronic inflammatory and a potentially malignant disorder of oral mucosa. Tumor necrosis factor-alpha (TNF- α) has been pointed as a key cytokine in OLP. OBJECTIVES: To evaluate whether the salivary levels of TNF- α were changed in patients with erosive oral lichen planus (EOLP). METHODOLOGY: A total of fourteen cases of EOLP with and without dysplastic changes, along with seven age matched healthy controls were included in this study. Samples of unstimulated saliva was collected, centrifuged and analyzed with enzyme linked immunosorbent assay (ELISA). RESULTS: There was a statistically significant increase in the salivary levels of TNF- α in patients of the two study groups when compared to the control group. CONCLUSIONS: TNF- α plays a role in pathogenesis and carcinogenesis of EOLP, and can be used as a useful marker and indicator for subjects at high risk to develop OLP as a potentially malignant lesion.
Keywords
Oral lichen planus; Potentially malignant; Tumor necrosis factor; saliva
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