Youssef, M., Darwish, Z., Fahmy, R., El Sayed, N. (2019). THE EFFECT OF TOPICALLY APPLIED HYALURONIC ACID GEL VERSUS TOPICAL CORTICOSTEROID IN THE TREATMENT OF EROSIVE ORAL LICHEN PLANUS. test, 44(1), 57-63. doi: 10.21608/adjalexu.2019.57577
Mohamed I. Youssef; Zeinab E. Darwish; Rania A. Fahmy; Naguiba M. El Sayed. "THE EFFECT OF TOPICALLY APPLIED HYALURONIC ACID GEL VERSUS TOPICAL CORTICOSTEROID IN THE TREATMENT OF EROSIVE ORAL LICHEN PLANUS". test, 44, 1, 2019, 57-63. doi: 10.21608/adjalexu.2019.57577
Youssef, M., Darwish, Z., Fahmy, R., El Sayed, N. (2019). 'THE EFFECT OF TOPICALLY APPLIED HYALURONIC ACID GEL VERSUS TOPICAL CORTICOSTEROID IN THE TREATMENT OF EROSIVE ORAL LICHEN PLANUS', test, 44(1), pp. 57-63. doi: 10.21608/adjalexu.2019.57577
Youssef, M., Darwish, Z., Fahmy, R., El Sayed, N. THE EFFECT OF TOPICALLY APPLIED HYALURONIC ACID GEL VERSUS TOPICAL CORTICOSTEROID IN THE TREATMENT OF EROSIVE ORAL LICHEN PLANUS. test, 2019; 44(1): 57-63. doi: 10.21608/adjalexu.2019.57577

THE EFFECT OF TOPICALLY APPLIED HYALURONIC ACID GEL VERSUS TOPICAL CORTICOSTEROID IN THE TREATMENT OF EROSIVE ORAL LICHEN PLANUS

Alexandria Dental Journal
Article 10, Volume 44, Issue 1, April 2019, Pages 57-63    PDF (274.45 K)
Document Type: Original Article
DOI: 10.21608/adjalexu.2019.57577
Authors
Mohamed I. Youssef* 1; Zeinab E. Darwish2; Rania A. Fahmy3; Naguiba M. El Sayed4
1-Faculty of Dentistry, Alexandria University
2-Professor of Oral Pathology, Faculty of Dentistry Alexandria University
3-Lecturer of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry, Alexandria University
4-Professor of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry Alexandria University
Abstract
INTRODUCTION: Oral lichen planus is a common chronic inflammatory muco-cutaneous disease. Although the cause of oral lichen planus is not well known, T-lymphocyte infiltrate suggests a cell mediated immunological damage to basal cell layer of the epithelium. Its suggested treatment is topical corticosteroid. A promising new treatment for oral lichen planus [OLP] is the topical application of hyaluronic acid [HA], which has shown beneficial effect on wound healing. OBJECTIVES: to evaluate the effect of hyaluronic acid gel in the treatment of erosive oral lichen planus in comparison with topically applied corticosteroids. MATERIALS AND METHODS: a randomized, parallel, controlled clinical study was conducted on twenty patients who were randomly divided into two groups. Group I received topical application of corticosteroid (triamcinolone acetonide) 4-5 daily, for 28 days and Group II was similarly treated using hyaluronic acid 0.2% gel. Subjective symptom and Visual Analogue Scale (VAS) were recorded at base line, after 10 days and at 3 months. The objective sign clinical score was recorded at baseline, 1 and 3 months post –treatment. RESULTS: Both groups showed decrease in the lesion size and symptoms of OLP. The HA treated group showed a significantly higher decrease in the pain score in comparison to the corticosteroid treated group. Regarding the healing score, the corticosteroid group showed superior results than that shown with the HA. CONCLUSIONS: HA 0.2% gel is effective in the treatment of OLP, it resulted in a decrease in symptoms and signs of the disease. HA resulted in more control of pain when compared to topical corticosteroid.
Keywords
Hyaluronic acid gel; topical corticosteroid; Oral lichen planus
References
  1. Bajaj DR, Khoso NA, Devrajani BR, Matlani BL, Lohana P. Oral lichen planus: a clinical study. J Coll Physicians Surg Pak. 2010;20:154-7.
  2. Le Cleach L, Chosidow O. Clinical practice. Lichen planus. N Engl J Med. 2012;366:723-32.
  3. Bagan J, Compilato D, Paderni C, Campisi G, Panzarella V, Picciotti M, et al. Topical therapies for oral lichen planus management and their efficacy: a narrative review. Curr Pharm Des. 2012;18:5470-80.
  4. Sugerman P, Sabage N. Oral lichen planus: causes, diagnosis and management. Australian dental journal. 2002;47:290-7.
  5. Oliveira Alves MG, Almeida JD, Balducci I, Guimarães Cabral LA. Oral lichen planus: A retrospective study of 110 Brazilian patients. BMC Research Notes. 2010;3:1-4.
  6. Gonzalez-Moles MA, Scully C. Vesiculo-erosive oral mucosal disease--management with topical corticosteroids: (2) Protocols, monitoring of effects and adverse reactions, and the future. J Dent Res. 2005;84:302- 8.
  7. Nolan A, Badminton J, Maguire J, Seymour RA. The efficacy of topical hyaluronic acid in the management of oral lichen planus. J Oral Pathol Med. 2009;38:299-303.
  8. Bourguignon LY, Ramez M, Gilad E, Singleton PA, Man MQ, Crumrine DA, et al. Hyaluronan-CD44 interaction stimulates keratinocyte differentiation, lamellar body formation/secretion, and permeability barrier homeostasis. J Invest Dermatol. 2006;126:1356-65.
  9. Culp LA, Murray BA, Rollins BJ. Fibronectin and proteoglycans as determinants of cell‐substratum adhesion. Journal of supramolecular structure. 1979;11:401-27.
  10. Smith T. Gelclair: managing the symptoms of oral mucositis. Hosp Med. 2001;62:623-6.
  11. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J. 2013;10:159-66.
  12. Liguori V, Guillemin C, Pesce GF, Mirimanoff RO, Bernier J. Double-blind, randomized clinical study comparing hyaluronic acid cream to placebo in patients treated with radiotherapy. Radiother Oncol. 1997;42:155- 61.
  13. Rad M, Hashemipoor MA, Mojtahedi A, Zarei MR, Chamani G, Kakoei S, et al. Correlation between clinical and histopathologic diagnoses of oral lichen planus based on modified WHO diagnostic criteria. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:796-800.
  14. Edwards PC, Kelsch R. Oral lichen planus: clinical presentation and management. J Can Dent Assoc. 2002;68:494-9.
  15. Aghahosseini F, Arbabi-Kalati F, Fashtami LA, Djavid GE, Fateh M, Beitollahi JM. Methylene blue-mediated photodynamic therapy: a possible alternative treatment for oral lichen planus. Lasers Surg Med. 2006;38:33-8.
  16. Huskisson EC, Jones J, Scott PJ. Application of visualanalogue scales to the measurement of functional capacity. Rheumatol Rehabil. 1976;15:185-7.
  17. Passeron T, Zakaria W, Ostovari N, Mantoux F, Lacour JP, Ortonne JP. Treatment of erosive oral lichen planus by the 308 nm excimer laser. Lasers Surg Med. 2004;34:205.
  18. Canto AM, Muller H, Freitas RR, Santos PS. Oral lichen planus (OLP): clinical and complementary diagnosis. An Bras Dermatol. 2010;85:669-75.
  19. Thongprasom K, Carrozzo M, Furness S, Lodi G. Interventions for treating oral lichen planus. Cochrane Database Syst Rev. 2011:CD001168.
  20. Hegarty AM, Hodgson TA, Lewsey JD, Porter SR. Fluticasone propionate spray and betamethasone sodium phosphate mouthrinse: a randomized crossover study for the treatment of symptomatic oral lichen planus. J Am Acad Dermatol. 2002;47:271-9.
  21. Vente C, Reich K, Rupprecht R, Neumann C. Erosive mucosal lichen planus: response to topical treatment with tacrolimus. Br J Dermatol. 1999;140:338-42.
  22. Brown MB, Jones SA, Weijiang H, Martin GP, editors. Hyaluronan: Investigations into the mode of action of hyaluronan in topical drug delivery. ACS symposium series; 2006: Oxford University Press.
  23. David-Raoudi M, Tranchepain F, Deschrevel B, Vincent JC, Bogdanowicz P, Boumediene K, et al. Differential effects of hyaluronan and its fragments on fibroblasts: relation to wound healing. Wound Repair Regen. 2008;16:274-87.
  24. Shetty RR, Burde KN, Guttal KS. The Efficacy of Topical Hyaluronic Acid 0.2% in the Management of Symptomatic Oral Lichen Planus. J Clin Diagn Res. 2016;10:ZC46-50.
  25. Normile D. Ethics. Clinical trials guidelines at odds with U.S. policy. Science. 2008;322:516.
  26. Voigt J, Driver VR. Hyaluronic acid derivatives and their healing effect on burns, epithelial surgical wounds, and chronic wounds: A systematic review and meta‐analysis of randomized controlled trials. Wound Repair and Regeneration. 2012;20:317-31.
  27. Juhasz I, Zoltan P, Erdei I. Treatment of partial thickness burns with Zn-hyaluronan: lessons of a clinical pilot study. Ann Burns Fire Disasters. 2012;25:82-5.
  28. Shimizu N, Ishida D, Yamamoto A, Kuroyanagi M, Kuroyanagi Y. Development of a functional wound dressing composed of hyaluronic acid spongy sheet containing bioactive components: evaluation of wound healing potential in animal tests. J Biomater Sci Polym Ed. 2014;25:1278-91.
  29. Yang G, Espandar L, Mamalis N, Prestwich GD. A crosslinked hyaluronan gel accelerates healing of corneal epithelial abrasion and alkali burn injuries in rabbits. Vet Ophthalmol. 2010;13:144-50.
  30. Anilkumar T, Muhamed J, Jose A, Jyothi A, Mohanan P, Krishnan LK. Advantages of hyaluronic acid as a component of fibrin sheet for care of acute wound. Biologicals. 2011;39:81-8.
  31. Neuman MG, Nanau RM, Oruna-Sanchez L, Coto G. Hyaluronic acid and wound healing. J Pharm Pharm Sci. 2015;18:53-60.
  32. Sun LT, Friedrich E, Heuslein JL, Pferdehirt RE, Dangelo NM, Natesan S, et al. Reduction of burn progression with topical delivery of (antitumor necrosis factor-alpha)- hyaluronic acid conjugates. Wound Repair Regen. 2012;20:563-72.
  33. Hoffmann A, Hoing JL, Newman M, Simman R. Role of Hyaluronic Acid Treatment in the Prevention of Keloid Scarring. J Am Coll Clin Wound Spec. 2012;4:23-31.
  34. Weinstein-Oppenheimer CR, Aceituno AR, Brown DI, Acevedo C, Ceriani R, Fuentes MA, et al. The effect of an autologous cellular gel-matrix integrated implant system on wound healing. J Transl Med. 2010;8:59.
Statistics
Article View: 852
PDF Download: 1,245