Mahareek, O., Fahmi, A., Abdur-Rahman, M., Shemis, M. (2019). Synthesis, Characterization and Optimization of PCL ˗ based Nanocapsules for Delivery of Anticancer Chemotheraputic Drug. test, 36(1), 412-423. doi: 10.21608/jsrs.2019.57774
Omnia Mahareek; Abdelgawad Fahmi; Mariam Abdur-Rahman; Mohamed Shemis. "Synthesis, Characterization and Optimization of PCL ˗ based Nanocapsules for Delivery of Anticancer Chemotheraputic Drug". test, 36, 1, 2019, 412-423. doi: 10.21608/jsrs.2019.57774
Mahareek, O., Fahmi, A., Abdur-Rahman, M., Shemis, M. (2019). 'Synthesis, Characterization and Optimization of PCL ˗ based Nanocapsules for Delivery of Anticancer Chemotheraputic Drug', test, 36(1), pp. 412-423. doi: 10.21608/jsrs.2019.57774
Mahareek, O., Fahmi, A., Abdur-Rahman, M., Shemis, M. Synthesis, Characterization and Optimization of PCL ˗ based Nanocapsules for Delivery of Anticancer Chemotheraputic Drug. test, 2019; 36(1): 412-423. doi: 10.21608/jsrs.2019.57774

Synthesis, Characterization and Optimization of PCL ˗ based Nanocapsules for Delivery of Anticancer Chemotheraputic Drug

Journal of Scientific Research in Science
Article 26, Volume 36, Issue 1, April 2019, Pages 412-423    PDF (758.95 K)
Document Type: Original Article
DOI: 10.21608/jsrs.2019.57774
Authors
Omnia Mahareek* 1; Abdelgawad Fahmi2; Mariam Abdur-Rahman3; Mohamed Shemis4
1Deparrtment of Biochemistry and Molecular biology, Theodor Bilharz Research Institute, Egypt.
2Department of Chemistry, Faculty of Science, Cairo University, Egypt.
32Department of Chemistry, Faculty of Science, Cairo University, Egypt.
4Deparrtment of Biochemistry and Molecular biology, Theodor Bilharz Research Institute,
Abstract
Nanocapsules based drug delivery system has provided an efficient tools in cancer treatment in recent times. The toxicity of anticancer drugs can be decreased through nano-encapsulation using polymeric nanocapsules. This study aimed to synthesis, optimization and characterization of doxorubicin (Dox) loaded biodegradable polycaprolactone (PCL) nanocapsules. Dox loaded PCL nanocapsules were prepared by double emulsion method using dichloromethane as the organic solvent, and polyvinyl alcohol as the external aqueous phase. Formulation parameter such as the effect of weight ratio of drug to polymer was optimized for the synthesis of Dox-PCL nanocapsules. Different weight ratio of Dox loaded PCL nanocapsules (1:20), (1:50) and (3:10) were prepared. Dox-PCL nanocapsules of weight ratio of 3:10 mg had higher DL of 16.88 % than other cases and its average size determined by dynamic light scattering (DLS) was 212 nm. The TEM image revealed that the prepared nanocapsules were spherical in shape in all cases. Also, ZPs were greater in case of Dox-PCL with ratio of 3:10 mg than other cases, which suggests good stability these synthesized nanocapsules. Finally, these results indicate that the properties such as DL %, morphology, size and surface charge of the nanocapsules colloidal suspension were better with decreasing the amount of PCL and increasing the amount of Dox.
 

 
Keywords
Doxorubicin; Polycaprolactone; Double emulsion; Nanocapsules; Chemotherapeutic drug
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