Mousa, S., Ismail, N., Zayed, M. (2020). Development of Carbon Paste Electrodes for the Selective Determination of Venlafaxine and Its Metabolite Desvenlafaxine in their Pure and Pharmaceutical Formulations. test, 63(5), 1833-1848. doi: 10.21608/ejchem.2019.17417.2067
shimaa Mousa; Nahla Sayed Ismail; mohamed A. Zayed. "Development of Carbon Paste Electrodes for the Selective Determination of Venlafaxine and Its Metabolite Desvenlafaxine in their Pure and Pharmaceutical Formulations". test, 63, 5, 2020, 1833-1848. doi: 10.21608/ejchem.2019.17417.2067
Mousa, S., Ismail, N., Zayed, M. (2020). 'Development of Carbon Paste Electrodes for the Selective Determination of Venlafaxine and Its Metabolite Desvenlafaxine in their Pure and Pharmaceutical Formulations', test, 63(5), pp. 1833-1848. doi: 10.21608/ejchem.2019.17417.2067
Mousa, S., Ismail, N., Zayed, M. Development of Carbon Paste Electrodes for the Selective Determination of Venlafaxine and Its Metabolite Desvenlafaxine in their Pure and Pharmaceutical Formulations. test, 2020; 63(5): 1833-1848. doi: 10.21608/ejchem.2019.17417.2067

Development of Carbon Paste Electrodes for the Selective Determination of Venlafaxine and Its Metabolite Desvenlafaxine in their Pure and Pharmaceutical Formulations

Egyptian Journal of Chemistry
Article 19, Volume 63, Issue 5, May 2020, Pages 1833-1848    PDF (1.27 M)
Document Type: Original Article
DOI: 10.21608/ejchem.2019.17417.2067
Authors
shimaa Mousa1; Nahla Sayed Ismail* 2; mohamed A. Zayed3
11National Organization for Drug Control and Research (NODCAR), Giza, Egypt
2analytical chemistry,NODCAR
3Department of chemistry, Faculty of Science, Cairo University (D.Sc. Anal.Chem.)
Abstract
Abstract
Desvenlafaxine succinate anhydrous is a cyclohexanol and phenol derivative and metabolite of venlafaxine that functions as a Serotonin and Norepinephrine Reuptake Inhibitor (SNRI) class and is used as an anti-depressive agent. This research introduces design and construction of four ion-selective carbon paste electrodes for fast and simple determination of Venlafaxine and its metabolite Desvenlafaxine in pure and in their pharmaceutical formulations. The best electrodes performance were obtained with a paste composition of 55.8% graphite, 37.2% dibutylphethalate (DBP), and 7% ion-pair for Desvenlafaxine-borate electrode DV-TPB and 46.5% graphite, 46.5% o-NPOE, and 5% ion-associate for Venlafaxine-borate electrode V-TPB, and paste composition of 46.5% graphite, 46.5% DBP, and 7% ion-associate for Desvenlafaxine–phosphotungistate electrode DV-PT and 47.5% graphite, 47.5% o-NPOE, and 5% ion-associate for venlafaxine–phosphotungistate V-PT electrode. These four electrodes illustrated fast, stable and Nernstian response over concentration range of 5.96×10-5-1.00×10-2 mol L-1 for both V-TPB and V-PT sensors and 5.66 ×10-4 -1×10-2 mol L-1 for both DV-TPB and DV-PT sensors. Validation of methods shows suitability of the sensors for application in quality control analysis of drug in pharmaceutical formulation. The obtained results were compared with official method using F- and t-tests.
Keywords
Venlafaxine; Desvenlafaxine succinate; ion-selective electrodes; metabolite; and ion-associate
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