Ki 67 Expression in Molecular Sub types of Breast Cancer in Patients of Zagazig University Hospitals | ||
| Zagazig University Medical Journal | ||
| Article 3, Volume 28, Issue 6.2, November 2022, Pages 8-17 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2019.17094.1527 | ||
| Authors | ||
| Magdy Ismail Abdel Rehim1; Anan Fathi2; nelly Mohamed said3; Moamer Faraj Kday* 4 | ||
| 1Pathology Dept. Faculty of medicine- Zagazig University- Zagazig- Egypt | ||
| 2pathology, Faculty of Medicine, Zagazig University | ||
| 3pathology department - zagazig university | ||
| 4pathology - faculty of medicine - Zagazig university | ||
| Abstract | ||
| Ki67 representing the proliferation of the cells for the active tumors. Moreover, a lot of studies performed to determine its prognostic role. This study evaluated the significance and prognostic role of Ki67 among molecular subtypes of breast cancer. Methods: Ki67 was measured in 58 cases of primary breast cancers in pathology department of Zagazig University from 2016-2018. These patients were evaluated for Estrogen Receptor, Progesterone Receptor, and HER2. Ki67 was divided to high and low according to percentage levels: < 20% and ≥ 20%. Result: Among 58 cases studied, the patients’ age ranged from 22 to 72 years, (50%) cases were classified luminal A subtype, (24.1%) cases as luminal B, (15.5%) cases as HER2 enriched, and (10.3%) cases triple-negative. Luminal tumors featured a prevalence of lower tumor grades (grades 1and 2), whereas high tumor grade (grade 3) predominated among the HER2-enriched and triple-negative subtypes (66.7% for each). Triple-negative was significantly associated with younger ages. We observed that high expression of Ki67 appears to be associated with tumor size, high histological grade & stage, positive lymph node, distant metastasis, histological type, hormonal receptor negativity and poor Nottingham Prognostic Index. Conclusion: We concluded that Luminal A breast cancer is the most common molecular subtype in patients of Zagazig University Hospitals, similar to other international and local studies, triple-negative subtype is the most aggressive subtype associated with poorer prognostic parameters, and Ki67 may be considered as a valuable biomarker in breast cancer patients. Key words: breast cancer, Ki67, molecular subtypes, prognosis | ||
| Keywords | ||
| breast cancer; Ki67; molecular subtypes; prognosis | ||
|
Statistics Article View: 393 |
||
