Helal, E., Aljalaud, N., Abdelaziz, M., Zakaria, A. (2019). Effect of Both Phytoestrogen and Xenoestrogen on Some Sexual Hormones in Male Albino Rats and Illustration of The Effect of Arctium Lappa L (A. Lappa) on Their Actions. test, 77(5), 5520-5527. doi: 10.21608/ejhm.2019.60262
Eman G.E. Helal; Nora Abdulaziz Aljalaud; Mohamed A. Abdelaziz; Abeer Zakaria. "Effect of Both Phytoestrogen and Xenoestrogen on Some Sexual Hormones in Male Albino Rats and Illustration of The Effect of Arctium Lappa L (A. Lappa) on Their Actions". test, 77, 5, 2019, 5520-5527. doi: 10.21608/ejhm.2019.60262
Helal, E., Aljalaud, N., Abdelaziz, M., Zakaria, A. (2019). 'Effect of Both Phytoestrogen and Xenoestrogen on Some Sexual Hormones in Male Albino Rats and Illustration of The Effect of Arctium Lappa L (A. Lappa) on Their Actions', test, 77(5), pp. 5520-5527. doi: 10.21608/ejhm.2019.60262
Helal, E., Aljalaud, N., Abdelaziz, M., Zakaria, A. Effect of Both Phytoestrogen and Xenoestrogen on Some Sexual Hormones in Male Albino Rats and Illustration of The Effect of Arctium Lappa L (A. Lappa) on Their Actions. test, 2019; 77(5): 5520-5527. doi: 10.21608/ejhm.2019.60262

Effect of Both Phytoestrogen and Xenoestrogen on Some Sexual Hormones in Male Albino Rats and Illustration of The Effect of Arctium Lappa L (A. Lappa) on Their Actions

The Egyptian Journal of Hospital Medicine
Article 2, Volume 77, Issue 5, October 2019, Pages 5520-5527    PDF (491.07 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2019.60262
Authors
Eman G.E. Helal* 1; Nora Abdulaziz Aljalaud2; Mohamed A. Abdelaziz3; Abeer Zakaria1
1Zoology Department, Faculty of Science, Al- Azhar University (Girls)
2Biology Department Collage of Science Imam Abdulrahman Bin Fasial University
3Physiology Department, Faculty of Medicine, Al-Azhar University
Abstract
Background: Xenoestrogens are chemically distinct industrial products potentially able to disrupt the endocrine system by mimicking the action of endogenous steroid hormones. Phytoestrogens are naturally occurring non-steroidal plant chemicals that can act like the female hormone estrogen. Arctium lappa (burdock) root has traditionally been recommended as an aphrodisiac agent. Objective: The aim of the study was to clarify the effect of both bisphenol-A (BPA) and anise oil together on some sexual hormones and illustration the effect of A. lappa on their actions. Materials and methods: The study was conducted on thirty male albino rats. The animals were divided into three groups: Group I, control untreated group, Group II, rats treated with bisphenol-A and anise oil and Group III, rats treated with BPA and anise oil in addition to A. lappa. Blood samples were collected to estimate biochemical parameters. Results: The biochemical results showed highly significant increase (p < 0.01) in the activities of ALT, AST, urea, creatinine, FSH, prolactin, total cholesterol, triglycerides, LDLC, VLDL, LDL/HDL and TC/HDL levels. While, there was highly significant decrease (p < 0.01) in HDLC, total protein, albumin, globulin, testosterone and, LH. All these results turned back to the normal values after receiving the A. lappa as compared to normal group. Conclusion: it could be concluded that phytoestrogen and xenoestrogen have undesirable effects and it's recommended to minimize the utilization of these compound to protect people from its hazardous effects.
Keywords
BPA; Anise oil; A. lappa; Hormonal assay; biochemical parameters
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