Isolated Extramedullary Relapse in a Case of Acute Myeloid Leukemia Following Allogeneic Stem Cell Transplantation | ||
| Research in Oncology | ||
| Article 10, Volume 14, Issue 1, June 2018, Pages 47-49 PDF (559.17 K) | ||
| Document Type: Case reports | ||
| DOI: 10.21608/resoncol.2018.2231.1041 | ||
| Authors | ||
| Raafat Abdel-Malek* 1; Rehab Sayed2; Shady Anis3 | ||
| 1Clinical Oncology Department, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt | ||
| 2Clinical Oncology Department, Arab Organization for Industry Hospital, Cairo, Egypt | ||
| 3Pathology Department, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt | ||
| Abstract | ||
| Background: Acute myeloid leukemia (AML) is the commonest acute leukemia in adults. Allogeneic stem cell transplantation (ASCT) is a curative option for a subset of these patients. Case Presentation: We report the case of a 36 years old female patient who presented in April 2014 with pancytopenia. Investigations revealed that she had AML (M6). She achieved complete remission with induction chemotherapy which was followed by four cycles of consolidation chemotherapy until a human leukocyte antigen-matched donor was available. She underwent ASCT in January 2015. After 14 months, in March 2016, she presented with left breast and right parapharyngeal masses. Histopathological examination of the excised mass showed infiltration with myeloid cells and the bone marrow was normocellular without leukemic infiltration. She received radiotherapy to the affected breast and the cervical region followed by chemotherapy with good response. Conclusion: AML relapse following ASCT may be in the form of isolated Extramedullary disease. Further research is needed to optimize the management of these cases. | ||
| Keywords | ||
| Acute Myeloid Leukemia; Allogeneic stem cell transplant; Extramedullary relapse | ||
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