Response of Chronic Myeloid Leukemia's Patient to Different Types of Tyrosine Kinase Inhibitors | ||
| The Medical Journal of Cairo University | ||
| Article 49, Volume 86, December, December 2018, Pages 3779-3785 PDF (584.54 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjcu.2018.61494 | ||
| Authors | ||
| OSAMA A. IBRAHIM, M.D.; RANIA M. HAFEZ, M.D.; MARWA I. KHALAF, M.D.; MARWA A. MAHMOUD, M.Sc. | ||
| The Departments of Internal Medicine* and Clinical Oncology**, Faculty of Medicine, Assiut University Hospital, Assiut, Egypt | ||
| Abstract | ||
| Abstract Background: Chronic Myeloid Leukemia (CML) is a proliferative neoplasm with an incidence of one to two cases per 100,000 adults. It accounts for approximately 15% of newly diagnosed cases of leukemia in adults, it is a serious and life-threatening condition, but with the introduction of tyrosine kinase inhibitors, there is much better life expectancy with low incidence of mortality and morbidity. Aim of Study: Retrospective study to determine the re-sponse of CML patients to Imatinib and Nilotinib as a second lines of TKIS. Patients and Methods: Records of CML patients who attended Assiut University Clinical Hematology Unit and Clinical Oncology Unit from 2014 to 2016 were revised and evaluated for complete hematological response, Partial Cy-togenetic Response (PCR), Complete Cytogenetic Response (CCR) and Major Molecular Response (MMR). The study evaluated the response of CML patients to two types of tyrosine kinase inhibitors; imatinib and Nilotinib as a second line therapy either by increasing the dose of imatinib 400mg to 800mg and Nilotinib 600mg to 800mg or shifting to the other line. Results: Administration of Nilotinib 600mg/day or 800 mg/day achieved a higher percentage of MMR than imatinib (p=<0.001). Conclusion: Nilotinib is a selective efficient second line TKI drug after failure or tolerance to Imatinib as it is more effective than imatinib as a second line therapy either by increasing the dose or shifting to it regarding MMR with a p-value 0.04. The development of TKIs has changed the natural history of CML patients with improvement in the overall survival and life style. | ||
| Keywords | ||
| Chronic myeloid leukemia – Tyrosine kinase inhibitors – Major molecular response – Nilotinib – Imatinib | ||
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