Importance of Serum Osteocalcin as Early Biomarker for Osteopenia in Preterm Neonates Receiving Total Parenteral Nutrition | ||
| Zagazig University Medical Journal | ||
| Article 14, Volume 28, Issue 3, May 2022, Pages 497-504 PDF (359.45 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2019.18105.1585 | ||
| Authors | ||
| Nehad Dyaa Al Deen Mekkawy* 1; Wafaa Fathi Elsaeed2; Hanan Samir Ahmed3; Atef Mohammed khaliel4 | ||
| 1pediatrices and neonatolology, zagazig faculty of medicine | ||
| 2pediatric, faculty of medicine, zagazig university, zagazig, egypt | ||
| 3Clinical Pathology Faculty of Medicine , Zagazig University,zagazig ,Egypt | ||
| 4Pediatrics Faculty of Medicine , Zagazig University, zagazig, Egypt | ||
| Abstract | ||
| Background: Prematurity osteopenia is known by bone mineral content reduction, which occurs especially due to decreased mineral stores in premature infants that may be excessive by increased mineral demands in the neonatal period. Thus, the aim of this study was to detect the significance of osteocalcin as an early biomarker for preterm neonates receiving total parenteral nutrition (T.P.N) with osteopenia. Material and Methods: A Cohort study on preterm neonates receiving TPN carried out in Neonatal Intensive Care Unit of Pediatric Department, Faculty of Medicine of Zagazig University Hospitals in the period from April 2016 to September 2018. This study included 30 preterm neonates receiving (TPN) of both sexes with birth weight ≤1500gm. Comprehensive serum osteocalcin, alkaline phosphatase (ALP), calcium and phosphorus were assessed before and after TPN. Results: we found that serum levels of calcium and phosphorous showed a significant decrease after given TPN (P=0.045, P | ||
| Keywords | ||
| Osteopenia; prematurity; Total Parenteral Nutrition (TPN); Osteocalcin; alkaline phosphatase | ||
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