Evaluation of Lactoferrin Immunomodulatory Effect on the Immune Response of Broiler Chickens | ||
| Suez Canal Veterinary Medical Journal. SCVMJ | ||
| Article 11, Volume 22, Issue 1, June 2017, Pages 135-146 PDF (833.7 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/scvmj.2017.62452 | ||
| Authors | ||
| Mohamed Enany1; Abd El Azeem El Gammal1; Rafeek Solimane2; Ashgan El Sissi3; Asmaa Hebashy3 | ||
| 1Department of Bacteriology, Immunology and Mycology,Faculty of Veterinary Medicine, Suez Canal University | ||
| 2Department of Microbiology, Faculty of Veterinary Medicine, Cairo University | ||
| 3Department of Immunology,Animal Health Research Institute, Dokki | ||
| Abstract | ||
| Immunomodulators are substances that able to regulate or modulate immune responses. In order to investigate the lactoferrin effect on the immune system of broiler chickens,one hundred twenty (1-day-old) chicks of both sexes were randomly allocated into 2 dietary groups (60 chicks/group), group1 (G1): chicks were offered basal diets and kept as control group, group2 (G2): Chicks were offered basal diets supplemented with lactoferrin (250mg/kg diet for 6 weeks). Evaluating the effects of dietary supplementation with lactoferrin on growth performance of broiler chicks, humeral immunity by measuring antibody titer against Newcastle (ND) and Avian influenza (AIV)vaccine, and on innate immunity by measuring some functions of peripheral blood monocytes (PBM) as phagocytic activity, fungicidal activity, nitric oxide (NO) production and reactive oxygen species (ROS) production by tetrazolium reduction test. To study antibacterial effect of lactoferrin, challenge test was carried out using virulent E. coli strain .The results revealed that, lactoferrin improve growth performance and could stimulate the humeral immunity by increasing the antibody titer aginst ND and AIV vaccine .Also lactoferrin could enhance the innate immunity by significant increasing of phagocytic and Fungicidal activities of PBM and its production of ROS and NO. Lactoferrin have the ability to protect broiler chickens from virulent agents as E. coli. Therefore, lactoferrin may be used as immunostimulant, growth promoters and antibacterial agent in broiler chickens. | ||
| Keywords | ||
| Lactoferrin; Broiler chickens; E. coli; humera immunity; challenge test | ||
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