Role of Taurine in Male Reproductive System Performance in Adult Male Rats Exposed to Oxiative Stress by Hydrogen Peroxide | ||
| Journal of Applied Veterinary Sciences | ||
| Article 10, Volume 4, Issue 2, October 2019, Pages 71-79 PDF (362.42 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/javs.2019.62661 | ||
| Author | ||
| Nadhem A. H. Al-kassim* | ||
| Department of Physiology, Biochemistry and pharmacology/ College of Veterinary Medicine/ University of Mosul, Iraq | ||
| Abstract | ||
| The experiment has been conducted to study the role of taurine of the concentration (0.5 & 1%) in the performance of the male reproductive system of rats that are exposed to oxidative stress by hydrogen peroxide for six weeks. 32 albino adult male rats aged (12-14) weeks and weighing (252.3 +/- 27.08 gram), divided into four groups: Control Group:- this group is given natural water. Group (2): treated with (H2O2, 0.5%) in drinking water. Group (3): treated with (H2O2, 0.5%) by taurine (0.5%) in drinking water. Group (4): treated with (H2O2, 0.5%) by taurine (1%) in drinking water. The results reveal that this exposure with (0.5 % H2O2) has led to an significant decrease in the body weight and the ano – genital distance, the percentage weight of the testicles, head and tail of eqididymis, prostate gland, seminal vesicles, the percentage of live sperms, the number of Legdig and Sertoli cells, as well as the significant increase in the percentage of abnormal sperms and an significant decrease in the diameter of seminiferous tubules. Treatment with taurine (0.5 & 1%) has led to an significant improvement in the body weight, ano-genital distance, the percentage of the testicles weight, head and tail of eqididymis, prostate gland, seminal vesicles, the percentage of live sperms, the number of Legdig and Sertoli cells, as well as the significant decrease in the percentage of abnormal sperms and an significant increase in the diameter of seminiferous tubules in comparison with the treatment group by hydrogen peroxide. Treatment with taurine (1%) has led to an significant improvement of the sperm count and the percentage weight of the head and tail of the epididymis as well as the number of Legdig and Sertoli cells compared with the control group and the group of taurine (0.5%). | ||
| Keywords | ||
| ano–genital; eqididymis; taurine; prostate gland; Rats | ||
| References | ||
|
AL-MA'ATHEEDI, MOHMOOD SALIM MOHAMMAD SHEET, 2009. Effects of antioxidants on physiological characteristics in adult roosters exposed to oxidative stress) Msc. Thesis, college of veterinary medicine, university of mosul.
AL-SAEDY, ABD-AL-KAREEM 2001. Fertility and artificial insemination, 2nd edition college of veterinary medicine – university of mosul.
ALVAREZ JG, STOREY BT.1983. Taurine, hypotaurine, epinephrine and albumin inhibit lipid peroxidation in rabbit spermatozoa and protect against loss of motility. Biology of Reproduction. 29:548–555.
AZIZ, B. N. 2000. Effect of hydrogen peroxide induced oxidative stress on epiclidymal sperm of mice. Iraqi. J. Vet. Sci.,13(1): 61-65.
BALCH, J. M. D. AND BALCH, P. CN. C. 1997. Prescription for Nutritional Healing. Ed. Amy. Tecklenberg. New York, NY. Pengiun, Putnam, Inc., 3rd ed. 42-53.
BALCH,P.A. AND JAMES , F . 2000. Amino acids prescription for nutritional healing . Ed.Amy .C. Tecklenberg, New York ,NY.Pengium , Inc., 3rd ed. 42-53.
BEARDEN, HJ , FUGUANY,TW. AND WILLARD,ST. 2004. Applied animal Reproduction, 6th, ed Mississippi state University.
BOATMAN DE, BAVISTER DB, CRUZ E. 1990. Addition of hypotaurine can reactivate immotile golden hamster spermatozoa. Journal of Andrology. 11(1):66–72.
BOUSQUEST, P., FELDMAN, J., BLOCH, R. AND SCHWARTZ, J. 1981. Central cardiovascular effects of taurine: Comparison wih homotaurine and muscimol. J. Pharmacol. Exp. Ther., 219: 213-218.
BUCKINGHAM, K.W.1985. Effect of dietary poly unsaturated saturated fatty acid ratio and dietary vitamin E on lipid peroxidation in the rat. J. of Nutrition, 115: 1425-1435.
CARMEN, D. 2002. Nutrition. Atomic Doc. Publishing, USA. 8: 118-119.
CIERESZKO, A. AND DABROWSKI, K. 2000. Effect of ascorbic acid supplement in vitro on rainbow trout sperm viability. Aquaculture Int., 8(1) : 1-8.
FERI, B.1999. On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction. P.S.E.B.M., 222: 196-204.
FERRARI, C.K.B. 2000. Free radical, lipid peroxidation and antioxidant in apoptosis: Implication in cancer, cardiovascular, neurological diseases. Biol. Bratislava, 55(6): 581-590.
GILBERT, H.S.; STAMP, D.D. AND ROTH E.F. 1984. Amethod to correct for errors caused by generation of interfering compounds during erythrocytes lipid peroxidation. Analyt. Biochem., 137: 282-286.
HASSAN, S.M.; AL-KENNANY, E.R. AND AL-HAFEZ, H.A.K. 2000. Hydrogen peroxide – induced atherosclerosis in chicken : effect of vitamin C. Iraqi J. Vet. Sci., 13: 249-269.
HINTON BT. 1990. The testicular and epididymal luminal amino acid microenvironment in the rat. Journal of Andrology. 11(6):498–505.
HIPLER, U.C.; GORNIG, M.; HIPLER, B.; ROMER, W. AND SCHREIBER, G. 2000. Stimulation and scavestrogen-induced inhibition of reactive oxygen species generated by rat sertoli cells. Arch. Androl., 44: 147-154.
HOLMES RP, GOODMAN HO, SHIHABI ZK, JARROW JP. 1992. The taurine and hypotaurine content of human semen. Journal of Andrology. 13(3):289–292.
HSU, P.C.; LIU, M.Y.; HSU, C.C.; CHEN, L.Y. AND GUO, Y.L. 1998. Effect of vitamin E and / or vitamin C on reactive oxygen species related lead toxicity in the rat sperm. Toxicology, 128: 169-179.
HUXTABLE, R. J. AND SEBRING, L. A. 1983. Cardiovascular action of taurine. In: Kuriyama, K., Huxtable, R., Iwata, H. (eds.), Sulfur Amino Acids: Biochemical and Clinical Aspects. New York: Alan, R. Liss, 5-37.
ISYAKU, U.Y.; OKASHA, M.A.H.M.E.; AYO, J.O. AND OLORUNSHOLA, K.V.2009. Antioxidant vitamin C and E alleviate the toxicity induced by chronic sodium nitrate administration on sperm count and serum testosterone level in wistar rats. Europ. J. of Sci. Res., 25(1): 35-41.
JACOBSEN, JG,AND SMITH ,LH.1968. Biochemistry and physiology of taurine and taurine derivatives . Physio. Rev.,48:424-511.
KELSO, K.A.; NOBLE, R.C.; SPARKS, N.H.C. AND SPEAKE 1996. Lipid and antioxidant changes in semen of broiler fowl from 25 to 60 weeks of age. J. Reprod. Fertil., 106: 201-206.
LESS, D.; ME BARNES, D AND ECOX, J.1982. Testesterone concentration in plasma of rats deficient in vitamin E. J. Reprod. Fert., 66: 543 -45.
LI JH, LING YQ, FAN JJ, ZHANG XP, CUI S. 2006. Expression of cysteine sulfinate decarboxylase (CSD) in male reproductive organs of mice. Histochem and Cell Biology. 125:607–613.
LOBO, MVT,ALONSO FJM, RIO, RM. 2000. Immunohistochemical localization of taurine in the male reproductive organs of the rats . J. Histochem. Cytochem. 48(3):313-320.
LOVEN, D.P. AND OBERLEY, L.W. 1983. Free radical, insulin action and diabetes. In: superoxide dismutase and disease state Oberley L.W. ed., Boca. Reton, F.L. CRC., 151-190.
LUNA, L.G. 1968. Manual of histological staining methods of the Armed forces institute of pathology., 3rd ed., The Blackiston Division, McGraw Hill-Book Company, NewYork.
MAHALAKSHMI, K., PUSHPAKIRAN, G. AND ANUDRDHA, C. V. 2003. Taurine prevents acrylonitrile-induced oxidative stress in rat brain. Pol. J. Pharmacol., 55: 1037-1043.
MEIZEL S, LUI CW, WORKING PK, MRSNY RJ. 1980. Taurine and hypotaurine: their effects on motility, capacitation and the acrosome reaction of hamster sperm in vitro and their presence in sperm and reproductive tract fluids of several mammals. Development, Growth & Differentiation. 22(3):483–494.
MEIZEL S. 1985. Molecules that initiate or help stimulate the acrosome reaction by their interaction with the mammalian sperm surface. American Journal of Anatomy. 174(3):285–302
MOCHIZUKI, H., ODA, H. AND YOKOGOSHI, H. 2000. Dietary taurine alters ascorbic acid metabolism in rats fed diets containing polychlorinated biphenyls. J. Nutr., 130(4): 873-876.
MRSNY RJ, MEIZEL S. 1985. Inhibition of hamster sperm Na+, K+-ATPase activity by taurine and hypotaurine. Life Science. 36(3):271–275.
NISHIMURA, K.; MATSUMIYA, K.; TSUJIMURA, A.; KOGA, M.; KITAMURA, M. AND OKUYAMA, A. 2001. Association of Selenoprotein P with testosterone production in cultured leydig cells. Arch. Androl., 47(1): 67-76.
OERTEL WH, SCHMECHEL DE, WEISE VK, RANSOM DH, TAPPAZ ML, KRUTZSCH HC, KOPIN IJ. 1981. Comparison of cysteine sulphinic acid decarboxylase isoenzymes and glutamic acid decarboxylase in rat liver and brain. Neuroscience. 6(12):2701–2714.doi:10.1016/0306-522(81)90114.
PASANTES-MORALES H, LOPEZ-COLOME AM, SALCEDA R, MANDEL P. 1976. Cysteine sulphinate decarboxylase in chick and rat retina during development. Journal of Neurochemistry. 27(5):1103–1106. doi: 10.1111/j.1471-4159.1976.tb00315.x.
PETROSIAN, A. M. AND HAROUTOUNIAN, J. E. 2000. Taurine as a universal carrier of lipid soluble vitamins: a hypothesis. Amino Acide, 19, 409-420.
PIAO, J. H., HILL, K. E., HUNT, R. W. AND BURK, R. F. 1990. Effect of selenium deficiency on tissue taurine concentration and urinary taurine excretion in the rat. J. Nutr. Biochem., 1(8): 427-432.
PUTZ, O ., SCHWARTZ, CB LEBLANE,GA, COOPER,RL AND PRINS, GS. 2001. Neonatal low and high dose exposure to estradiol benzoate in the male rat:11 effects on male puberty and reproductive tract. Bio.Repr.,65: 1506 – 1517.
QASAB- BASHI, 2009. Study of estrogen and testosterone treatment in the neonatal male rats on the spermatogenesis and sexual behavioral. Msc. Thesis, college of veterinary medicine, university of mosul.
RAIHA, N., RASSIN,D., HEINONEN,K., AND GAULL, G.E.1975. Milk protein quality and quantity : Biochemical and growth effects in low birth weight infant (LBWI ) . Pediatr.Res ., 9: 370.
SAKAMOTO, J AND HASHIMOTO,K.1986. Reproductive toxicity of arylamide and related compounds in mice :Effect on fertility and sperm morphology Arch.Toxcol.,59:201-205 .
SATOH, H. AND SPERELAKIS, N. 1998. Review of some actions of taurine on ion channels of cardiac muscle cells and others. Gen. Pharmac., 30: 451-463. Militante, J. D. and Lombardini, J. B. (2002). Taurine: evidence of physiological function in the retina. Nutr. Neurosci., 5(2): 75-90.
SHIRO, V. 1993. Vitamin E. its usefulness in health and curing Disease. Japan Scientific Societies Press. 41-50.
SIKKA, S.C. 1996. Oxidative stress and role of antioxidants in normal and abnormal sperm function. Frontiers in Bioscience., 1: 78-86.
SKOPNIK, H., KUSENBACH, G., BERGT, U., FRIEDRICHS, F., STUHLSATZ, H., DOHMEN, H., HEIMANN, G. 1991. Taurine supplementation in cystic fibrosis (CF): effect on vitamin E absorption kinetics. Klin.padiatr., 203(1): 28-32.
SURAI, P.F.; NOBLE, R.C. AND SPEAKE, B.K. 1996. Tissue – specific differences in antioxidant distribution and susceptibility to lipid peroxidation during development of the chick embryo. Biochem. Acta. 1304(1) : 1-10.
WISINIWSKI, AB, KLEIN, SL ,LAKSHMANAN, Y AND GEARHART,JP.2003. Exposure to genistein during gestation and lactation demasculinizes the reproductive system in rats . J.of Urology 169 : 1582 – 1586 .
YANG JC, WU GF, FENG Y, SUN CM, LIN SM, HU JM. CSD2010. mRNA expression in rat testis and the effect of taurine on testosterone secretion. Amino Acids. 39(1):155–160. | ||
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