The Interplay between Apelin/APJ System and Renin Angiotensin System in Protection Against Cold Restraint Stress Induced Gastric Ulcers in Adult Male Rats | ||
| The Medical Journal of Cairo University | ||
| Article 134, Volume 86, December, December 2018, Pages 4503-4511 PDF (761.72 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjcu.2018.63152 | ||
| Authors | ||
| NANCY F. SAMIR, M.D.; FATMA E. IBRAHIM, M.D.; LAILA A. RASHED, M.D. | ||
| The Departments of Physiology* and Biochemistry**, Faculty of Medicine, Cairo University, Egypt | ||
| Abstract | ||
| Abstract Background: Activation of Renin Angiotensin System (RAS) is one of the main mechanisms involved in the devel-opment of stress induced gastric ulcers. Aim of the Study: This study aimed to examine the effect of inhibitors of RAS in protection against stress-induced gastric ulcers and the interplay between RAS and apelin/APJ system in gastric protection. Material and Methods: Twenty-four adult male rats were divided into 4 groups: Control, Cold Restraint Stress (CRS), Angiotensin Converting Enzyme (ACE) inhibitor + CRS and Angiotensin II receptor type 1 (AT-1) blocker + CRS. Ulcer index, PH, acidity and mucin content of gastric fluid were measured. MDA, NO, PGE2, apelin level, COX-2 and Angi-otensin 1-7 gene expression assessment were done. Gastric tissues were assessed histopathologically. Results: Pre-treatment of rats with either capoten or micardis for 14 days prior to CRS significantly reduced ulcer index, gastric acidity, MDA and COX-2 expression; while PH, gastric acidity, mucin content, NO, PGE2, gastric apelin level and Angiotensin 1-7 gene expression were significantly elevated. Conclusion: Our findings suggest the integration between apelin/APJ system and RAS in protection against gastric ulceration. | ||
| Keywords | ||
| Renin angiotensin system – Apelin – Angiotensin 1-7 – Gastric stress ulcers | ||
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