Allogeneic injectable Platelet Rich Plasma improves neurotization index in a rat model | ||
| Zagazig University Medical Journal | ||
| Article 10, Volume 28, Issue 6.2, November 2022, Pages 50-57 PDF (539.11 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2019.18582.1602 | ||
| Authors | ||
| Mustafa Muhammed Mustafa* 1; raafat abd ellatif anani2; Ahmed Mohamed Aly3; Mohamed Ibrahim Abdelhamid mansy4 | ||
| 1General surgey,faculty of medicine,zagazig university. | ||
| 2Faculty of Medicine, Zagazig University, Department of plastic Surgery, Sharkia Egypt | ||
| 3Faculty of Medicine, Zagazig University, Department of Plastic and Microscopic Surgery, Sharkia Egypt | ||
| 4Faculty of Medicine, Zagazig University, Department of General Surgery, Sharkia Egypt | ||
| Abstract | ||
| Background: To detect the effect of injectable allogenic PRP in improvement of neurotization index in rat model. Methods: This was Experimental and histopathological study that had included (21) .Sciatic nerve on both sides was cut transversely repaired microscopically. In all rats there was two groups Group (1): The left side (control group) we did Primary repair only but in Group (2): The Right side (PRP group): Activated PRP was injected under epineurium after primary repair Results: There was a significant relationship between the count of nerve fibers distally in both groups and a Non-significant relationship proximally. In the control group G1 the neurotization index was (92.3 %) but in PRP group it was G2 (94.7%), and this statistics was considered valuable (P = .021). A reduction was noticed in the count of the new nerve fibers distal to the repair in G1 (126.6) and G2 (138) compared with that of the proximal segments of the same groups (137and 145.67respectively which were statistically significant in both groups (P = 0.00). Conclusion: We found in our statistics a significant differences in the count of regenerated nerve fibers in (PRP group) distally and proximally and more in the distal count. PRP has aroused as a possible treatment option for peripheral nerve injury. Because of our results, PRP can be used as adjuvant therapy that helps in peripheral nerve regeneration in cases of primary nerve repair in humans. | ||
| Keywords | ||
| peripheral nerve injuries; platelet rich plasma (PRP); nerve regeneration | ||
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