ENHANCEMENT OF DISSOLUTION AND ANALGESIC ACTIVITY OF CELECOXIB USING TERNARY SYSTEM | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 7, Volume 32, Issue 1, June 2009, Pages 141-152 PDF (495.22 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2009.63352 | ||
| Author | ||
| Mohamed A. Amin | ||
| Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al- Azhar University, Assiut, Egypt | ||
| Abstract | ||
| The purpose of the present study is to investigate the drug loaded solid dispersion system consisting of a drug, a carrier and a surfactant. Solid dispersions of a water insoluble drug celecoxib (CX) with PVP 40000, namely binary solid dispersion systems, was prepared at different ratios of drug to carrier [(1:1), (1:3), and (1:5)]. Polysorbate 80, a nonionic surfactant, was incorporated into the binary solid dispersion systems as a third component to obtain the ternary solid dispersion system. The solubilizing and absorption enhancement properties of ternary solid dispersion system have been investigated. The prepared solid dispersion systems (binary or ternary), at various drug- polymer ratios by mixing or co-precipitation, were characterized by differential scanning calorimetery and X- ray diffractometry. The results show a remarkably improved dissolution of the drug from the ternary solid dispersion systems when compared to the binary solid dispersion systems. The therapeutic activity of the ternary system was evaluated using acetic acid- induced writhing method. In-vivo experiments in mice demonstrated that the investigated ternary system (drug, polymer and surfactant) shows a greater reduction of acetic acid- induced writhing in comparison with pure drug. Moreover, the ternary system of (CX) demonstrated antiwrithing potency 1.45 times higher than the respective binary system. Thus, the solubilizing power, the dissolution effect, and the analgesic effect were enhanced upon the addition of the investigated surfactant to the binary system of celecoxib and the polymer. | ||
|
Statistics Article View: 110 PDF Download: 182 |
||
