Improvement of Adsorptive Voltammetric Methods for Determination of Midodrine by Carbon Paste Electrode Modified with Gold Nano Particles in Presence of Β-Cyclodextrin | ||
| Egyptian Journal of Chemistry | ||
| Article 15, Volume 63, Issue 6, June 2020, Pages 2185-2199 PDF (1.32 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2019.17052.2131 | ||
| Author | ||
| Waheed M Salem* | ||
| Chemistry Department, faculty of science, Dam an hour University | ||
| Abstract | ||
| An effective novel electrochemical sensor constructed for the determination of Midodrine hydrochloride drug using differential pulse voltammetry. The sensor is based on a carbon paste electrode modified with gold nanoparticles and β-cyclodextrin in Britton-Robinson buffer of pH 3.0. The effect of various experimental parameters on the constructed electrodes properties including pH, β-cyclodextrin concentration and scan rate was investigated. At the optimum conditions, a linear range from 3.0 x 10-6 to 3.2 x 10-4 mol L-1 with correlation coefficient of 0.9997 and a detection limit of 5.14 x 10-7 mol L-1were obtained. The modified electrodes were used for microdetermination of the drug in tablets and spiked human urine samples with appropriate an acceptable recovery, reproducibility, selectivity and robustness. Potential strength investigation was achieved using 0.1 M of HCl. | ||
| Keywords | ||
| Gold nanoparticles modified electrode; Midodrine hydrochloride; β-cyclodextrin; Differential Pulse Voltammetry; Urine analysis | ||
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