Sherif, H., El Masry, N., Kawana, K., Khalil, N. (2019). EFFECT OF BISPHOSPHONATES ON THE ALVEOLAR BONE OF RATS WITH GLUCOCORTICOIDS INDUCED OSTEOPOROSIS. test, 44(3), 65-70. doi: 10.21608/adjalexu.2019.63560
Hagar Sherif; Nawal A. El Masry; Khadiga Y. Kawana; Nesma M. Khalil. "EFFECT OF BISPHOSPHONATES ON THE ALVEOLAR BONE OF RATS WITH GLUCOCORTICOIDS INDUCED OSTEOPOROSIS". test, 44, 3, 2019, 65-70. doi: 10.21608/adjalexu.2019.63560
Sherif, H., El Masry, N., Kawana, K., Khalil, N. (2019). 'EFFECT OF BISPHOSPHONATES ON THE ALVEOLAR BONE OF RATS WITH GLUCOCORTICOIDS INDUCED OSTEOPOROSIS', test, 44(3), pp. 65-70. doi: 10.21608/adjalexu.2019.63560
Sherif, H., El Masry, N., Kawana, K., Khalil, N. EFFECT OF BISPHOSPHONATES ON THE ALVEOLAR BONE OF RATS WITH GLUCOCORTICOIDS INDUCED OSTEOPOROSIS. test, 2019; 44(3): 65-70. doi: 10.21608/adjalexu.2019.63560

EFFECT OF BISPHOSPHONATES ON THE ALVEOLAR BONE OF RATS WITH GLUCOCORTICOIDS INDUCED OSTEOPOROSIS

Alexandria Dental Journal
Article 13, Volume 44, Issue 3, December 2019, Pages 65-70    PDF (511.72 K)
Document Type: Original Article
DOI: 10.21608/adjalexu.2019.63560
Authors
Hagar Sherif* 1; Nawal A. El Masry2; Khadiga Y. Kawana2; Nesma M. Khalil3
1Assistant Lecturer of Oral biology, Faculty of Dentistry, Alexandria University.
2Professor of Oral Biology, Faculty of Dentistry, Alexandria University.
3Lecturer of Oral Biology, Faculty of Dentistry, Alexandria University
Abstract
INTRODUCTION: Bone is a unique tissue that undergoes frequent remodeling. An imbalance between bone formation and resorption results in osteoporosis. Glucocorticoids (GCs) are widely used clinically as anti-inflammatory and immunomodulatory. However, their prolonged use may induce osteoporosis. Currently, evidences revealed that also the alveolar processes are subject to osteoporosis. Bisphosphonates, such as Alendronate, Risedronate and Zoledronate, are recommended by several international guidelines as the first-line therapy for the prevention and treatment of generalized glucocorticoids induced osteoporosis (GIOP). OBJECTIVES: To evaluate the effect of bisphosphonates (Risedronate) on the alveolar bone of rats with glucocorticoids induced osteoporosis. MATERIALS AND METHODS: Thirty female albino rats were divided into 3 equal groups (10 rats each) as follows: Group I: control group. Group II: glucocorticoids group (Dexamethasone 0.6mg/kg twice/week subcutaneously). Group III: Risedronate treated group; rats were given Dexamethasone (0.6mg/kg twice/week subcutaneously) and Risedronate (1mg/kg/day orally). After 12 weeks, rats were euthanized, and the mandibular alveolar bone was evaluated histologically by light microscope and ultra-structurally by scanning electron microscopy and energy dispersive X-ray (EDX) microanalysis. RESULTS: Group II showed deterioration of the alveolar bone in comparison to the control group I. The alveolar bone structure in Group III rats, treated by bisphosphonates (Risedronate), showed remarkable improvement both histologically and ultrastructurally in comparison to group II. Moreover, EDX analysis revealed a significant decrease of calcium levels in group II in comparison to group I. However, in group III calcium levels were restored to normal levels comparable to the control group I. CONCLUSIONS: Glucocorticoids intake induces loss of the alveolar bone; which, could be counterbalanced by bisphosphonates.
Keywords
bisphosphonates; glucocorticoids; Osteoporosis; alveolar bone
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