SYNTHESIS AND IN-VITRO CYTOTOXIC ACTIVITY OF NOVEL BENZO[b]PHENAZINE-6,11-DIONE AND 1,4- NAPHTHOQUINONE DERIVATIVES | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 4, Volume 31, Issue 1, June 2008, Pages 69-80 PDF (196.59 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2008.64215 | ||
| Authors | ||
| Maha M. A. Khalifa* 1; Magda M. F. Ismail1; Eman Noaman2 | ||
| 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, Egypt | ||
| 2Department of Radiation Biology, Natural Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt | ||
| Abstract | ||
| 5,12-Dihydrobenzophenazine-6,11-diones,2-Arylamino-3- chloro-1,4-naphthoquinones and 6,11-dihydrobenzo[b]phenazine- 6,11-diones, were synthesized from 2,3-dichloro-1,4-naphthoquinone and arylamines/phenylenediamines. Studying the cytotoxicity using EAC and human cell lines revealed that 5,12- dihydrobenzo[b]phenazine-6,11-dione (3) and 3-chloro-2-(2- pyridylamino)-1,4-naphthoquinone (10) showed selective cytotoxicity against the human lung carcinoma cell line (H460) superior to doxorubicin. Compound 3 (16.25 uM) was 1.3 times higher than that of doxorubicin. However, IC50 value of compound 10 was 9.90 uM which was 2 times higher than that (20.10 uM) of doxorubicin. These compounds were inactive against liver carcinoma (HEPG2), brain tumor (U251), cervix carcinoma (HELA) and breast carcinoma (MCF7) cell lines. | ||
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