FORMULATION AND EVALUATION OF KETOPROFEN CELLULOSE ACETATE MICROCAPSULES | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 5, Volume 31, Issue 1, June 2008, Pages 81-91 PDF (322.34 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2008.64216 | ||
| Authors | ||
| Wael A. Abdelhafez; Khaled I. Saleh I. Saleh | ||
| Department of Pharmaceutics, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt | ||
| Abstract | ||
| Ketoprofen is a potent non-steroidal anti-inflammatory, analgesic, and antipyretic drug used for treatment of various rheumatic diseases and painful conditions. It is rapidly absorbed regardless the route of administration. Its half life is only 1-2 hrs after oral administration. The aim of this work was to formulate some controlled release oral dosage forms containing ketoprofen. Cellulose acetate was chosen for this purpose. Ketoprofen-cellulose acetate microcapsules were prepared by solvent evaporation technique. Polyvinyl alcohol was used as an emulsifier. The prepared microcapsules were evaluated in terms of their release and surface characteristics. Also, the anti-inflammatory activity of ketoprofen was evaluated using the carrageenan-induced rat's pawedema method. The release of ketoprofen from the microcapsules was pH dependant and decreased by increasing the polymer content and by increasing the organic phase volume. The particle size of the produced microcapsules was decreased by increasing the volume of organic phase, whereas it was increased by increasing the polymer content. In conclusion, these results suggested that microencapsulation of ketoprofen using cellulose acetate could be a useful approach for controlled release of the drug. | ||
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