ESTIMATION OF SOME CARCINOGENIC PESTICIDES OVERLOAD IN HUMAN ADIPOSE TISSUE | ||
| Biochemistry Letters | ||
| Article 4, Volume 5, Issue 1, 2009, Pages 34-50 PDF (293.14 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/blj.2009.64235 | ||
| Author | ||
| Hussien, M. EL-Shafei | ||
| General Authority for Fish Resources Development, Port Said, Egypt. | ||
| Abstract | ||
| Polychlorinated biphenyls (PCBs) are potentially hazardous compounds in the environmental pollution for human beings persistent. The high lipophilicity and the resistance to biodegradation of PCBs allow the bioaccumulation of these chemicals in the fatty tissues of organisms.To test the hypothesis that the amount and quality of organochlorine residues in adipose tissue related to the tumor incidence, the PCBs body burden in patients was studied. The objective of this study was to determine the levels of PCBs in the adipose tissue of different patients lived in Delta Egypt especially Al- Dakhelia, Al-Garbia, and Damietta which were the most probably used pesticides. For this purpose, levels of eight major persistent PCB congeners (IUPAC Numbers: 101, 118, 138, 153,170, 180, 183, 187) and the DDT metabolite p, p' DDE, p, p' DDD and p, p' DDT ,HCH were measured in 25 patients adipose tissue samples by gas chromatography with electron capture detection (GCECD). The concentrations of PCB 28, PCB 52 and PCB 101 were found to be higher than those found in industrialized countries. Also breast cancer women showed higher median Hussien, M. EL-Shafei 35 values of (138, 153 and 180) with respect to brain, lung, liver, and prostate cancer men. A positive correlation (P <0.05) was found between the age of donors and the tissue levels of PCBs 28,118,138, 153,170,180,183,187 and 188, and also their is a positive correlation of both p, p' DDT and DDE with age in females. The results are compared with the similar studies from other countries, the higher level of these compounds detected in this study seems to be similar to results obtained in other countries. | ||
| Keywords | ||
| human adipose tissue; pollution; polychlorinated biphenyl; congeners; isomer | ||
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