Platelet Rich Plasma in Repeated Implantation Failure in Women with Thin Endometrium Thickness | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 15, Volume 77, Issue 6, October 2019, Pages 5873-5875 PDF (216.82 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2019.64633 | ||
| Authors | ||
| Mahmoud A. El Hamedi1; Hesham A. Salem* 2 | ||
| 1Department of Obstetrics and Gynecology Faculty of Medicine, Zawia University, Libya | ||
| 2Department of Obstetrics and Gynecology Faculty of Medicine, Tanta University, Egypt | ||
| Abstract | ||
| Background: repeated implantation failure (RIF) is a major challenge in reproductive medicine. Platelet rich plasma (PRP) was able to promote the endometrial growth and improve pregnancy outcome of patients with thin endometrium. Aim of the study: it was to evaluate the effectiveness of intrauterine infusion of PRP in treatment of thin endometrium in frozen-thawed embryo (FTE) transfer. Patients and Methods: the study included 10 infertile patients with thin endometrium (<7mm) in Frozen Embryo Transfer (FET) program. Estradiol valerate 12 mg/d was started on day 3 of menstrual cycle. PRP was prepared from autologous blood and infused into the uterine cavity. Endometrial thickness was re-assessed and if the endometrial thickness wasn’t satisfactory infusion of PRP was repeated 2-4 times. Cleavage stage embryos were transferred on the 3 rd day after progesterone administration, and blastocysts were transferred on the 5th day after progesterone administration. Results: the endometrial thickness increased after PRP infusion in all the patients, and reached >7mm on the day of progesterone administration. Sixty percent of the patients became pregnant; 83.3% continued pregnancy and 16.7% experienced missed abortion. Conclusion: intrauterine PRP may be effective in promoting endometrial growth, endometrial thickness, and improving pregnancy out come in repeated implantation failure. | ||
| Keywords | ||
| platelet rich plasma; Repeated; Implantation Failure; Endometrial Thickness | ||
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