SYNTHESIS OF SOME POTENTIAL ANTIESTROGENIC AGENTS | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 6, Volume 28, Issue 1, June 2005, Pages 27-35 PDF (178.28 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2005.65181 | ||
| Authors | ||
| Hany M. Safwat; Gehan H. Hegazy; Ghaneya S. Hassan | ||
| Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt | ||
| Abstract | ||
| Some novel steroidal arylidene derivatives were synthesized and representative examples were tested for their antiestrogenic activity. The active compounds were subjected for antitumor activity screening. The compounds tested displayed aromatase inhibitory activity as shown by decrease in estradiol and increase in testosterone levels. Further, some compounds were tested for androgenic/anabolic activity. The steroids used for preparation of these arylidene derivatives are the clinically applied: levo-Norgestrel, Testosterone, Mesterolone and Norethisterone. | ||
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