Ahmed, S., Mesbah, M., Youssef, D., Khalifa, S. (2006). CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF THE RED SEA SPONGE NEGOMBATA CORTICATA. test, 29(1), 151-165. doi: 10.21608/bfsa.2006.65189
Safwat Ahmed; Mostafa Mesbah; Diaa Youssef; Sherief Khalifa. "CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF THE RED SEA SPONGE NEGOMBATA CORTICATA". test, 29, 1, 2006, 151-165. doi: 10.21608/bfsa.2006.65189
Ahmed, S., Mesbah, M., Youssef, D., Khalifa, S. (2006). 'CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF THE RED SEA SPONGE NEGOMBATA CORTICATA', test, 29(1), pp. 151-165. doi: 10.21608/bfsa.2006.65189
Ahmed, S., Mesbah, M., Youssef, D., Khalifa, S. CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF THE RED SEA SPONGE NEGOMBATA CORTICATA. test, 2006; 29(1): 151-165. doi: 10.21608/bfsa.2006.65189

CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF THE RED SEA SPONGE NEGOMBATA CORTICATA

Bulletin of Pharmaceutical Sciences Assiut University
Article 11, Volume 29, Issue 1, 2006, Pages 151-165    PDF (260.43 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2006.65189
Authors
Safwat Ahmed; Mostafa Mesbah; Diaa Youssef; Sherief Khalifa*
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
Abstract
Two new metabolites, a diglyceride ester, corticaglyceride (1) and a sphingolipid, corticaceramide (5) were isolated and characterized from the Red Sea sponge Negombata corticata (Carter). Other previously reported compounds including nervonic acid (2), 24-methylene cholesterol (3) and cholesterol (4) were also isolated for the first time from this genus. GLC analysis of the unsaponifiable matter revealed that it contained a high percentage of hydrocarbons (89.474%) with n-hexacosane as a major component (10.979%). Furthermore, the identified sterol represents 7.162%. GLC analysis of the fatty acid methyl esters revealed that nervonic acid is the major fatty acid (73.782%). Compound 3 showed anti-inflammatory activity, while compounds 1 and 5 showed mild anti-oxidant properties.
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