SPECTROPHOTOMETRIC DETERMINATION OF INDAPAMIDE AND CO-DERGOCRINE MESYLATE | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 2, Volume 27, Issue 1, June 2004, Pages 11-18 PDF (247.93 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2004.65385 | ||
| Author | ||
| Niveen A. Mohamed | ||
| Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt | ||
| Abstract | ||
| Two simple and sensitive spectrophotometric methods for the determination of indapamide and co-dergocrine in pure form and in pharmaceutical preparations were developed. The methods were based on the interaction of the cited drugs with either ammonium vanadate or sodium nitrite in strongly acidic media. The resulting coloured products were measured at 530 and 550 nm for indapamide and co-dergocrine respectively. The effect of different variables on the involved reactions and the colour development were studied and optimised. Beer,s law was obeyed in the range of 1.8-12 g ml-1 for indapamide using ammonium vanadate and sodium nitrite and 12-40 g ml-1 for co-dergocrine with both ammonium vanadate and sodium nitrite. The reproducibility and recovery of the methods are excellent. The methods were applied successfully to the determination of some commercially available dosage forms purchased from the local market. The results were comparable to those obtained by official or reported methods. | ||
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