Abdu-Allah, H., Abdel-Moty, S., El-Shorbagi, A., Abdel-Alim, A. (2005). SYNTHESIS OF TRIGONELLINE AND NICOTINAMIDE LINKED PRODRUGS OF 5-AMINOSALICYLIC ACID (5-ASA) WITH ANALGESIC AND ANTI-INFLAMMATORY EFFECTS. test, 28(2), 237-253. doi: 10.21608/bfsa.2005.65398
H. H. M. Abdu-Allah; S. G. Abdel-Moty; A. A. El-Shorbagi; A. M. Abdel-Alim. "SYNTHESIS OF TRIGONELLINE AND NICOTINAMIDE LINKED PRODRUGS OF 5-AMINOSALICYLIC ACID (5-ASA) WITH ANALGESIC AND ANTI-INFLAMMATORY EFFECTS". test, 28, 2, 2005, 237-253. doi: 10.21608/bfsa.2005.65398
Abdu-Allah, H., Abdel-Moty, S., El-Shorbagi, A., Abdel-Alim, A. (2005). 'SYNTHESIS OF TRIGONELLINE AND NICOTINAMIDE LINKED PRODRUGS OF 5-AMINOSALICYLIC ACID (5-ASA) WITH ANALGESIC AND ANTI-INFLAMMATORY EFFECTS', test, 28(2), pp. 237-253. doi: 10.21608/bfsa.2005.65398
Abdu-Allah, H., Abdel-Moty, S., El-Shorbagi, A., Abdel-Alim, A. SYNTHESIS OF TRIGONELLINE AND NICOTINAMIDE LINKED PRODRUGS OF 5-AMINOSALICYLIC ACID (5-ASA) WITH ANALGESIC AND ANTI-INFLAMMATORY EFFECTS. test, 2005; 28(2): 237-253. doi: 10.21608/bfsa.2005.65398

SYNTHESIS OF TRIGONELLINE AND NICOTINAMIDE LINKED PRODRUGS OF 5-AMINOSALICYLIC ACID (5-ASA) WITH ANALGESIC AND ANTI-INFLAMMATORY EFFECTS

Bulletin of Pharmaceutical Sciences Assiut University
Article 10, Volume 28, Issue 2, December 2005, Pages 237-253    PDF (371.6 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2005.65398
Authors
H. H. M. Abdu-Allah; S. G. Abdel-Moty; A. A. El-Shorbagi; A. M. Abdel-Alim*
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, University of Assiut, Assiut-71526, Egypt
Abstract
3-N-(4`-Hydroxy-3`-substituted phenyl)carbamoyl-1-methylpyridinium iodides (compds. 5b-j) and 3-carbamoyl-1-(N-(4`-hydroxy- 3`-substituted phenyl)carbamoyl) methyl pyridinium chlorides (compds. 7a-j) were synthesised and some of them were tested for their analgesic and antiinflammatory activities by hot plate test and carageenin-induced hind paw edema model, respectively. Compound 5b revealed the most potent analgesic and anti-inflammatory activities in comparison to sulfasalazine (SASP) and 5-ASA. In addition, ulcerogenicity, LD50, in-vivo and in vitro cleavage and pH stability of compound 5b were also determined.
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