Possible effects of erythropoietin on diabetic rats | ||
| Sohag Medical Journal | ||
| Article 10, Volume 24, Issue 1, January 2020, Pages 71-78 PDF (530.37 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/smj.2019.16102.1044 | ||
| Authors | ||
| walaa mohamed* 1; Ahmed Mostafa Mahmoud2; Hassan Elalaf3; Motamed Mahmoud4 | ||
| 1physiology department, faculty of medicine, sohag university | ||
| 2Department of Physiology, Faculty of Medicine, Sohag University, Sohag, Egypt. | ||
| 3physiology department, faculty of medicine, sohag university, sohag, Egypt | ||
| 4Department of Animal Behavior and Husbandry, Faculty of Veterinary Medicine, Sohag, University, Sohag, Egypt | ||
| Abstract | ||
| Abstract Background: Blood glucose is controlled by a pancreatic hormone, insulin, so any altered functions of pancreas are associated with disturbances in blood glucose level. Erythropoietin (EPO) is glycoprotein produced mainly by the kidney as a result of reduced intracellular oxygen. This study was designed to investigate the effect of EPO on blood glucose level in normal and streptozocin-induced diabetic rats. Materials and methods: Eighty mature rats were used in this study animals and randomly divided into 4 different isolated groups (n = 20); Group I was administered with normal saline and act as a control group. Animals were injected with streptozocin (STZ; 30 mg/kg, ip) to induce diabetes, and animals were treated with saline (Group II) or EPO (300 iu//kg, ip Group III) or insulin (3 iu//kg, s.c., group IV) respectively, for three successive weeks. STZ-induced diabetes was indicated by hyperglycemia. Further, Results: Three weeks after EPO treatment, there was enhanced blood glucose level associated with enhanced glucose tolerance and insulin sensitivity tests (P | ||
| Keywords | ||
| Keywords: Erythropoietin; Hypoglycemia; diabetes; rat | ||
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