FORMULATION DEVELOPMENT AND IN-VIVO EVALUATION OF BUCCOADHESIVE TABLETS OF VERAPAMIL HYDROCHLORIDE | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 10, Volume 27, Issue 2, December 2004, Pages 293-306 PDF (682.13 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2004.65455 | ||
| Author | ||
| Gamal A. El-Gindy | ||
| Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, Egyp | ||
| Abstract | ||
| Controlled-released buccoadhesive tablets of verapamil hydrochloride (VH) were obtained by incorporation of VH in suitable carrier systems standardised based on bioadhesion and dissolution. The carrier systems were formulated using carbomor 974P (CP974P) and hydroxypropylmethylcellulose (HPMC) or sodium carboxymethyl cellulose (NaCMC) or sodium alginate or guar gum as the bioadehsives. Mannitol and polyethylene glycol 6000 (PEG6000) were used as solubilizers singly or in combination. The effect of polymer concentration on the release profile and in-vitro bioadhesion of the matrix tablets was studied. Tablet formulations with carbomor 974P (5%), in combination with sodium alginate (20%) or HPMC (20%) showed 98% or 79% drug release, respectively after 6 h. The dissolution rate of the drug decreased by increasing CP974P concentration. Controlled-release buccoadhesive tablets containing VH were prepared and evaluated in order to achieve constant plasma concentrations during treatment of chronic hypertension and to improve the bioavailability of VH by the avoidance of hepatic first-pass metabolism. Pharmacological parameters and plasma concentration time curves obtained following buccal administration to rabbits of buccoadhesive tablets showed evidence of sustained release of VH. Bioavailability of VH was approximately two times that achieved after oral administraion of commercial tablets. The formulations were compared using pharmacokinetic parameters such as AUC, Cmax and Tmax values. | ||
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