MULTIVARIATE SPECTROPHOTOMETRIC ANALYSIS OF CERTAIN ANTIHYPERTENSIVE BINARY MIXTURES | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 2, Volume 26, Issue 1, June 2003, Pages 5-13 PDF (202.7 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2003.65463 | ||
| Authors | ||
| Abd El-Maaboud I. Mohamed* ; Samiha A. Hussein; Hanaa M. Abdel-Wadood | ||
| Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| A multivariate calibration method for the analysis of two hypotensive binary mixtures is described. The mixtures are composed of reserpine in combination either with hydrochlorothiazide or hydrofluomethiazide respectively. The components of the two mixtures show a considerable degree of spectral overlapping (83.5-88.5%). Resolution of the binary mixtures under investigation has been accomplished mainly by using classical least squares (CLS) analysis. The mixtures are simultaneously determined in three laboratory prepared tablet forms with high accuracy without interference from the commonly added excipients. Good recoveries were obtained with both synthetic mixtures and prepared tablets. The obtained results were compared with those obtained from official methods and found in good agreement with them. A comparison of the obtained results from CLS were performed with those obtained from principle component regression (PCR). | ||
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