Formulation and evaluation of ciprofloxacin hydrochloride suppositories | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 7, Volume 24, Issue 1, June 2001, Pages 47-54 PDF (248.23 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2001.65773 | ||
| Authors | ||
| M. Hassan1; N. M. Mahfouz2 | ||
| 1Departmeni of Pharmaceutics | ||
| 2Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiui University | ||
| Abstract | ||
| Formulation of the antibiotic, ciprofloxacin hydrochloride suppositories was carried out using different semisynthetic lipophilic bases as suppocire AM, suppocire CM, Novata B, Novata BD, Witepsol W35, and natural lipophilic base as Cocoa butter. The in-vitro release study of 100 mg ciprofloxacin hydrochloride suppository from these bases was performed in distd. water at 37° using thermostatically controlled mech. shaker water bath and the drug was measured at 278 nm. The results obtained revealed that suppocire AM gave the highest release rate followed by Novata BD, Novata B, Witepsol W35, Cocoa butter and Suppocire CM resp. The bioavailability of ciprofloxacin hydrochloride from suppositories contg. 100 mg of the drug after rectal administration in rabbits (1.5-2 kg), was carried out. HPLC procedures were adopted for the detn. of drug in plasma. The results obtained revealed that it was in agreement with the in-vitro data. The results showed that the drug was regularly absorbed and provided AUC ranging between 10.3 to 20.23 μ.hr./mL. Other pharmacokinetic parameters as Cmax, Tmax, Ka, Ke, | ||
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