Synthesis and chelating properties of substituted formyl pyridine thiosemicarbazones of potential biological activity | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 10, Volume 22, Issue 1, June 1999, Pages 97-108 PDF (344.84 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1999.66086 | ||
| Author | ||
| Hoda Y. Hassan | ||
| Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| The synthesis of a series of 4-(un)substituted thiosemicarbazones of 6-methyl-5-nitropyridine-2-carboxaldehyde, I (R = H, n-Bu, 4-ClC6H4, etc.), is reported by two different routes. The prepd. compds. were tested for their binding ability against Cu(II), Hg(II) and Zn(II). Four derivs. were tested for their complexing potentials in vivo. These compds. showed promising antidotal activities against Cu(II) relative to D-penicillamine. I (R = Ph) exhibited marked and significant increase in the mean threshold LD of CuSO4 in dose level (5 mg/kg) equal to the effect of D-penicillamine at dose level (30 mg/kg). The copper chelate and zinc chelate showed good activity against both Gram-pos. and Gram-neg. bacteria while the ligands showed activity against Gram-pos. bacteria only. | ||
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