El-Shorbagi, A. (2000). Disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thiones as lipophilic carriers for glutamine and glutamic acid. test, 23(1), 31-38. doi: 10.21608/bfsa.2000.66128
A. El-Shorbagi. "Disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thiones as lipophilic carriers for glutamine and glutamic acid". test, 23, 1, 2000, 31-38. doi: 10.21608/bfsa.2000.66128
El-Shorbagi, A. (2000). 'Disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thiones as lipophilic carriers for glutamine and glutamic acid', test, 23(1), pp. 31-38. doi: 10.21608/bfsa.2000.66128
El-Shorbagi, A. Disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thiones as lipophilic carriers for glutamine and glutamic acid. test, 2000; 23(1): 31-38. doi: 10.21608/bfsa.2000.66128

Disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thiones as lipophilic carriers for glutamine and glutamic acid

Bulletin of Pharmaceutical Sciences Assiut University
Article 4, Volume 23, Issue 1, June 2000, Pages 31-38    PDF (2.4 M)
Document Type: Original Article
DOI: 10.21608/bfsa.2000.66128
Author
A. El-Shorbagi
Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut-71526, Egypt
Abstract
L-​Glutamine and glutamic acid were incorporated in a tetrahydro-​2H-​1,​3,​5-​thiadiazine-​2-​thione (THTT) skeleton contg. different alkyl, cycloalkyl and aralkyl groups at N3 of the ring system.  These THTT derivs. revealed high lipophilicity compared with L-​glutamine and glutamic acid.  The degrdn. kinetics were studied -​in vitro- using aq. buffer solns. of pH values: 1.2, 6.0, 7.4, 7.8 and 9.0 at 37°.  From the pH profile, the degrdn. was accounted for, in terms of specific base-​catalyzed reactions.  All of the compds. however, showed higher acid-​stability.
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