Ahmed, S., Elsherei, M., Salah El Dine, R., Eltomy, S. (2019). Phytoconstituents, Hepatoprotective, and Antioxidant Activities of Euphorbia Cooperi N. E. Br.. test, 62(Special Issue (Part 2) Innovation in Chemistry), 831-840. doi: 10.21608/ejchem.2019.20992.2252
Shaimaa Rashad Ahmed; Moshera Mohammed Elsherei; Riham Salah El Dine; Sayed Eltomy. "Phytoconstituents, Hepatoprotective, and Antioxidant Activities of Euphorbia Cooperi N. E. Br.". test, 62, Special Issue (Part 2) Innovation in Chemistry, 2019, 831-840. doi: 10.21608/ejchem.2019.20992.2252
Ahmed, S., Elsherei, M., Salah El Dine, R., Eltomy, S. (2019). 'Phytoconstituents, Hepatoprotective, and Antioxidant Activities of Euphorbia Cooperi N. E. Br.', test, 62(Special Issue (Part 2) Innovation in Chemistry), pp. 831-840. doi: 10.21608/ejchem.2019.20992.2252
Ahmed, S., Elsherei, M., Salah El Dine, R., Eltomy, S. Phytoconstituents, Hepatoprotective, and Antioxidant Activities of Euphorbia Cooperi N. E. Br.. test, 2019; 62(Special Issue (Part 2) Innovation in Chemistry): 831-840. doi: 10.21608/ejchem.2019.20992.2252

Phytoconstituents, Hepatoprotective, and Antioxidant Activities of Euphorbia Cooperi N. E. Br.

Egyptian Journal of Chemistry
Article 28, Volume 62, Special Issue (Part 2) Innovation in Chemistry, December 2019, Pages 831-840    PDF (1.35 M)
Document Type: Original Article
DOI: 10.21608/ejchem.2019.20992.2252
Authors
Shaimaa Rashad Ahmed* 1; Moshera Mohammed Elsherei2; Riham Salah El Dine3; Sayed Eltomy4
1Department of Pharmacognosy, college of Pharmacy, Jouf University, Sakaka, KSA. Pharmacognosy Department, Faculty of Pharmacy, Cairo University, 11562, Kasr El-Ainy, Cairo, Egypt.
2Pharmacognosy Department, Faculty of Pharmacy, Cairo University, 11562, Kasr El-Ainy, Cairo, Egypt
3Pharmacognosy Department, Faculty of Pharmacy, Cairo University
4National Research centre Tanning lab.
Abstract
Exploring novel and effective therapies against liver damage with antioxidant activity is a point worth studying. The present study was aimed to evaluate the hepatoprotective and antioxidant activities of Euphorbia cooperi N. E. Br. aerial parts in paracetamol-induced hepatotoxicity mice and isolates its bioactive constituents. Our findings suggest for the potential antioxidant and hepatoprotective action of the n-butanol fraction of the plant as significantly (p < 0.05) prevented the increased serum marker enzymes AST, ALT and bilirubin levels, decreased hepatic MDA and recovered GSH levels. Chromatographic separation of n-butanol fraction led to isolation of seven compounds namely, Gallic acid, Bervifolin carboxylic acid, Kaempferol-3-O-ß-D-rutinoside, Corilagin, 3, 3'-dimethoxy ellagic acid, 3, 4, 4'-trimethoxy ellagic acid and Ellagic acid.The structure of isolated compounds was elucidated by physical and spectroscopic analysis and by comparison with the literature data. These compounds isolated for the first time from Euphorbia cooperi N. E. Br.
Keywords
Euphorbia cooperi; Hepatoprotective; antioxidant; Corilagin
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