Abdelaal, A., AlHamshary, A., El Shaer, O., Khalil, M., Younes, A. (2019). Urinary Interleukin‐6 as biomarker for diagnosis of acute pyelonephritis in children. test, 14(2), 41-46. doi: 10.21608/geget.2019.67038
Ashraf Abdelaal; Abd AlHamed AlHamshary; Osama El Shaer; Mustafa Khalil; Amr Younes. "Urinary Interleukin‐6 as biomarker for diagnosis of acute pyelonephritis in children". test, 14, 2, 2019, 41-46. doi: 10.21608/geget.2019.67038
Abdelaal, A., AlHamshary, A., El Shaer, O., Khalil, M., Younes, A. (2019). 'Urinary Interleukin‐6 as biomarker for diagnosis of acute pyelonephritis in children', test, 14(2), pp. 41-46. doi: 10.21608/geget.2019.67038
Abdelaal, A., AlHamshary, A., El Shaer, O., Khalil, M., Younes, A. Urinary Interleukin‐6 as biomarker for diagnosis of acute pyelonephritis in children. test, 2019; 14(2): 41-46. doi: 10.21608/geget.2019.67038

Urinary Interleukin‐6 as biomarker for diagnosis of acute pyelonephritis in children

GEGET
Article 7, Volume 14, Issue 2, December 2019, Pages 41-46    PDF (406.51 K)
Document Type: Original Article
DOI: 10.21608/geget.2019.67038
Authors
Ashraf Abdelaal* 1; Abd AlHamed AlHamshary2; Osama El Shaer3; Mustafa Khalil1; Amr Younes2
1Urology department, Faculty of Medicine, Benha University, Benha, Egypt.
2Pediatrics department, Faculty of Medicine, Benha University, Benha, Egypt.
3Clinical Pathology department, Faculty of Medicine, Benha University, Benha, Egypt. University
Abstract
Introduction
Urinary Interleukin-6 (IL-6) a pleiotropic cytokine with pro-inflammatory and immune-regulatory functions is a key mediator of inflammation in children with Urinary tract infection (UTI).
 
Aim of the study
The aim of this study is to estimate the role of urinary IL-6 (UIL-6) in diagnosis of acute UTI in children and its usefulness in differentiation between upper urinary tract infection (UUTI) (pyelonephritis) and lower urinary tract infection (LUTI) (cystitis).
 
Patients & Methods
This study conducted on a total 56 children divided into 36 patients suffering from UTI with mean age 4.3 ± 3.1 and 20 apparently healthy children age and sex matched with the cases. All patients were subjected to routine investigation and urine IL-6 assay.
 
Results
Urinary IL-6 was significantly higher in patients with UTI than control group, Sensitivity was 94.4 %, specificity of 92.1%, positive predictive value was 85%, negative predictive value was 97.2% anddiagnostic accuracy was 92.8% and the best cut off value >17 pg/ml. Also Urinary IL-6 was significantly higher in acute pyelonephritis (APN) in comparison to lower UTI cases and there was a positive correlation between urinary IL-6 level and fever, CRP, and leukocyte count [r = 0.623 P = 0.006, r = 0.816, P < 0.001 and r = 0.688,    P < 0.002 respectively]
 
Conclusion
Urinary IL-6 level may considered as a reliable biochemical marker to determine the severity of renal injury in APN as well as outcome of pediatric patients
 
 
Keywords
Urinary tract infection; pyelonephritis; Interleukin 6 (IL-6); children
Statistics
Article View: 308
PDF Download: 390