HISTOPATHOLOGICAL STUDY ON MICE EXPERIMENTALLY INFECTED WITH S. MANSONI AND TREATED BY NEEM AND MIRAZID | ||
| Journal of the Egyptian Society of Parasitology | ||
| Article 17, Volume 49, Issue 3, December 2019, Pages 631-642 PDF (1.44 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jesp.2019.68066 | ||
| Authors | ||
| HANAN TAHER HAMZA1, 2; FAYEZ M. SHALDOUM1, 3; WAFAA FAYEZ ABDEL HAMED4 | ||
| 1Department of Biology, College of Science, Jouf University, P.O. Box: 2014, Sakaka, Saudi Arabia.+ | ||
| 2Department of Zoology, Faculty of Science for Girls, Al-Azhar University, Cairo, Egypt | ||
| 3Department of Zoology, Faculty of Science for Boys, Cairo, Egypt. | ||
| 4Department of Environmental and Biological Sciences, Faculty of Home Economics4, Al-Azhar University, Cairo, Egypt. | ||
| Abstract | ||
| Generally, the parasitological markers showed that Neem (Azadirachta indica) and Mirazid (Commiphora molmol, MZ) were effective in reducing worms and eggs of Schistosoma mansoni. This study aimed to detect the histopathological improvement accompanied with using Neem and Mirazid to treat schistosomiasis. A total of 120 Swiss Albino mice were categorized into 10 groups: 5 groups infected with S. mansoni and either treated with only Neem (400 mg/kg), only MZ (500mg/kg), a combination of Neem and MZ, praziquantel (PZQ, 200 mg/kg) or not treated. Other 5 control groups were not infected but acquired the same treated doses as the above groups. The study was done in Department of Zoology, Faculty of Science, Al-Azhar University, Cairo, Egypt. Hematoxylin eosin and Masson’s trichrome stain stained sections were used to examine the histopathological changes in the intestine and liver of mice. The results showed marked decrease of liver fibrosis in groups of mice treated with neem and/or MZ. This was ensured by a significant diminution in number and diameters of granulomas, reduction in their fibrotic content accompanied with a reduction in total area of infection as compared to infected mice. | ||
| Keywords | ||
| Schistosomiasis; Commiphora molmol; MZ; Azadirachta indica; Liver fibrosis | ||
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