ALLAM, A., ANWAR, A., GHAIT, R., ABDEL RAHMAN, T., KABIEL, W., NASSER, H., HASSANY, M. (2019). A NON INVASIVE METHOD FOR DIAGNOSIS AND ASSESSMENT OF PORTAL HYPERTENSION IN EGYPTIAN CIRRHOTIC PATIENTS USING PLASMA MALONDIALDEHYDE LEVEL. test, 49(3), 661-668. doi: 10.21608/jesp.2019.68072
AHMED SAMIR ALLAM; AYMAN GAMIL ANWAR; RAMY SAMIR GHAIT; TAMER ABDEL RAHMAN; WALAA AHMED YOUSRY KABIEL; HAYTHAM M. NASSER; MOHAMED HASSANY. "A NON INVASIVE METHOD FOR DIAGNOSIS AND ASSESSMENT OF PORTAL HYPERTENSION IN EGYPTIAN CIRRHOTIC PATIENTS USING PLASMA MALONDIALDEHYDE LEVEL". test, 49, 3, 2019, 661-668. doi: 10.21608/jesp.2019.68072
ALLAM, A., ANWAR, A., GHAIT, R., ABDEL RAHMAN, T., KABIEL, W., NASSER, H., HASSANY, M. (2019). 'A NON INVASIVE METHOD FOR DIAGNOSIS AND ASSESSMENT OF PORTAL HYPERTENSION IN EGYPTIAN CIRRHOTIC PATIENTS USING PLASMA MALONDIALDEHYDE LEVEL', test, 49(3), pp. 661-668. doi: 10.21608/jesp.2019.68072
ALLAM, A., ANWAR, A., GHAIT, R., ABDEL RAHMAN, T., KABIEL, W., NASSER, H., HASSANY, M. A NON INVASIVE METHOD FOR DIAGNOSIS AND ASSESSMENT OF PORTAL HYPERTENSION IN EGYPTIAN CIRRHOTIC PATIENTS USING PLASMA MALONDIALDEHYDE LEVEL. test, 2019; 49(3): 661-668. doi: 10.21608/jesp.2019.68072

A NON INVASIVE METHOD FOR DIAGNOSIS AND ASSESSMENT OF PORTAL HYPERTENSION IN EGYPTIAN CIRRHOTIC PATIENTS USING PLASMA MALONDIALDEHYDE LEVEL

Journal of the Egyptian Society of Parasitology
Article 20, Volume 49, Issue 3, December 2019, Pages 661-668    PDF (353.51 K)
Document Type: Original Article
DOI: 10.21608/jesp.2019.68072
Authors
AHMED SAMIR ALLAM1; AYMAN GAMIL ANWAR1; RAMY SAMIR GHAIT1; TAMER ABDEL RAHMAN2; WALAA AHMED YOUSRY KABIEL3; HAYTHAM M. NASSER4; MOHAMED HASSANY5
1Departments of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo 11211, Egypt.
2Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo 11211, Egypt.
3Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo 11211, Egypt.
4Department of Radiology, Faculty of Medicine, Ain Shams University, Cairo 11211, Egypt.
5National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
Abstract
Liver cirrhosis is a common disease affecting Egyptian patients. Complications of liver cirrhosis usually start once portal hypertension increases. To the authors’ knowledge, there are no available non-invasive methods for assessment of the severity of portal hypertension. This study evaluated the value of plasma Malondialdehyde (MDA) - a lipid peroxide marker for oxidative stress, as a diagnostic biomarker, to assess severity of Portal Hypertension in Egyptian cirrhotic patients. It is a case-control study conducted on a total of 150 Egyptian patients divided into two groups. GI: 100 patients diagnosed as liver cirrhosis with esophageal varices proved by upper GIT endoscopy. GII: 50 normal controls. Serum MDA was measured by ELISA technique. The results showed that MDA assay between the two groups revealed significant statistical
difference between the two studied groups. Correlation between MDA and the clinical parameters in the cirrhotic group showed a significant positive correlation with ascites, Child Pugh score, varices grade, while there was no correlation with sex.
Keywords
Malondialdehyde; Portal Hypertension; Liver cirrhosis
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