M. Hassan, A., Heakal, B., Said, A., Aboulthana, W., Abdelmoaz, M. (2020). Comparative Study for Synthesis of Novel Mn (II), Co (II), Ni (II), Cu (II), Zn (II) and Zr (IV) Complexes under Conventional Methods and Microwave Irradiation and Evaluation of their Antimicrobial and Anticancer Activity. test, 63(7), 2533-2550. doi: 10.21608/ejchem.2020.21048.2255
Ali M. Hassan; Bassem Hussen Heakal; Ahmed Osman Said; Wael Mahmoud Aboulthana; Miral Ahmed Abdelmoaz. "Comparative Study for Synthesis of Novel Mn (II), Co (II), Ni (II), Cu (II), Zn (II) and Zr (IV) Complexes under Conventional Methods and Microwave Irradiation and Evaluation of their Antimicrobial and Anticancer Activity". test, 63, 7, 2020, 2533-2550. doi: 10.21608/ejchem.2020.21048.2255
M. Hassan, A., Heakal, B., Said, A., Aboulthana, W., Abdelmoaz, M. (2020). 'Comparative Study for Synthesis of Novel Mn (II), Co (II), Ni (II), Cu (II), Zn (II) and Zr (IV) Complexes under Conventional Methods and Microwave Irradiation and Evaluation of their Antimicrobial and Anticancer Activity', test, 63(7), pp. 2533-2550. doi: 10.21608/ejchem.2020.21048.2255
M. Hassan, A., Heakal, B., Said, A., Aboulthana, W., Abdelmoaz, M. Comparative Study for Synthesis of Novel Mn (II), Co (II), Ni (II), Cu (II), Zn (II) and Zr (IV) Complexes under Conventional Methods and Microwave Irradiation and Evaluation of their Antimicrobial and Anticancer Activity. test, 2020; 63(7): 2533-2550. doi: 10.21608/ejchem.2020.21048.2255

Comparative Study for Synthesis of Novel Mn (II), Co (II), Ni (II), Cu (II), Zn (II) and Zr (IV) Complexes under Conventional Methods and Microwave Irradiation and Evaluation of their Antimicrobial and Anticancer Activity

Egyptian Journal of Chemistry
Article 11, Volume 63, Issue 7, July 2020, Pages 2533-2550    PDF (3.66 M)
Document Type: Original Article
DOI: 10.21608/ejchem.2020.21048.2255
Authors
Ali M. Hassan1; Bassem Hussen Heakal2; Ahmed Osman Said* 3; Wael Mahmoud Aboulthana4; Miral Ahmed Abdelmoaz5
1Al Azhar University
2Research Laboratory, Cairo Oil Refining Company, Mostorod, Qaliobia, Egypt
3Senior researcher chemist, Greater Cairo Water Company, Cairo, Egypt
433 Bohouth St., P.O. 12622, Dokki, Giza, Egypt
5Pharmaceutical Chemistry Department, Faculty of pharmacy, Sinai University E-mail address
Abstract
A novel Schiff base ligand derived from o-Vanillin, N, N-Diethyl-p-phenylenediamine in 1:1 molar ratio, and its metal complexes of Mn (II), Co (II), Ni (II), Cu (II), Zn (II) and Zr (IV) were synthesized by microwave and conventional methods. The ligand and its complexes were characterized by elemental analysis, FT-IR, UV-Vis, 1HNMR, mass spectroscopy as well as Thermo-Gravimetric Analysis (TGA). The geometry of the proposed Structures of the chelates based on their Electronic spectra, Electron paramagnetic resonance (EPR) and magnetic moment. The thermal dehydration and decomposition of the complexes were studied kinetically using the integral method applying the Coats–Redfern and Horowitz Metzger equation. Study the Variation of magnetic susceptibility at Different temperature for Mn (II) and Co (II) complexes. Surface morphologies were analyzed by Scanning electron microscopy (SEM). The ligand and its metal complexes were screened for antimicrobial activity against Gram-positive, Gram-negative bacteria as well as fungi. Cu (II) complex achieved a brilliant inhibition zone diameter against E. coli almost reached the inhibition zone diameter record by standard positive control Cephalothin making it eligible for treatment of E. coli. Also, Cytotoxicity Evaluation was applied against two cell lines; human colon carcinoma (HCT) and liver cancer cells (HepG-2).
Keywords
Microwave synthesis; Metal complexes; Schiff base; o-vanillin; human colon carcinoma (HCT); HepG-2
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