FORMULATION AND EVALUATION OF CONTROLLED RELEASE AMINOPHYLLINE MATRIX TABLETS | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 4, Volume 20, Issue 2, December 1997, Pages 141-146 PDF (379.21 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1997.68751 | ||
| Authors | ||
| Ahmed Shaker Ali1; Adel Mohamed Ali2; Fergany Abd El-Hameed Mohammed1 | ||
| 1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
| 2Faculty of Pharmacy, Al-Isra University, Amman, Jordan | ||
| Abstract | ||
| Three matrix excipients namely: Hydroxypropylmethylcellulose (HPMC), sodium carboxymethyl cellulose (NaCMC) and egg albumin (EA) were utilized for the preparation of controlled release matrix tablets containing 200 mg of aminophylline. The prepared tablets were evaluated with respect to physical parameters and dissolution rate. All formulations showed acceptable physical parameters. The release rate was variable depending on the composition of the matrix tablet. There was no significant difference between the dissolution rates of the matrix tablets prepared with HPMC or EA. The lowest release rate was observed in case of the matrix tablets prepared using NaCMC either alone or in combination with either HPMC or EA. The dissolution data of the drug from most matrix tablets formulation were fitted to Higuchi diffusion model. | ||
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