SA., F., YH., I., N., A. (2010). GENOTOXICITY AND OXIDATIVE STRESS DUE TO EXPOSURE TO WOOD DUST AMONG CARPENTERS. test, 34(1), 83-95. doi: 10.21608/ejom.2010.689
Farahat SA.; Ibrahim YH.; Abdel-Latif N.. "GENOTOXICITY AND OXIDATIVE STRESS DUE TO EXPOSURE TO WOOD DUST AMONG CARPENTERS". test, 34, 1, 2010, 83-95. doi: 10.21608/ejom.2010.689
SA., F., YH., I., N., A. (2010). 'GENOTOXICITY AND OXIDATIVE STRESS DUE TO EXPOSURE TO WOOD DUST AMONG CARPENTERS', test, 34(1), pp. 83-95. doi: 10.21608/ejom.2010.689
SA., F., YH., I., N., A. GENOTOXICITY AND OXIDATIVE STRESS DUE TO EXPOSURE TO WOOD DUST AMONG CARPENTERS. test, 2010; 34(1): 83-95. doi: 10.21608/ejom.2010.689

GENOTOXICITY AND OXIDATIVE STRESS DUE TO EXPOSURE TO WOOD DUST AMONG CARPENTERS

Egyptian Journal of Occupational Medicine
Article 7, Volume 34, Issue 1, November 2010, Pages 83-95    PDF (194.6 K)
Document Type: Study paper
DOI: 10.21608/ejom.2010.689
Authors
Farahat SA.1; Ibrahim YH.2; Abdel-Latif N.2
1Dep. Industrial Med. and Occupational Diseases, Faculty of Medicine , Cairo University
2Air Research and Pollution Control Department, National Research Center
Abstract
Background: Genetic material is known to be one of the sensitive targets of wood dust. Objectives: This study aimed at measurement of the concentration of the respirable fraction of wood dust generated by different wood operating processes. In addition, the study investigated DNA damage among wood dust exposed carpenters and its relation
to oxidative stress (OS) induced by exposure to wood dust. Methods: Several air samples were collected from 4 carpentry workshops dealing with soft and hard types of unpolished wood and the respirable wood dust concentration was calculated. The study population consisted of an exposed group (n=28) and a matched control group (n=26).
Every participant underwent occupational questionnaire, assessment of chromosomal aberrations (CAs) (as an index for DNA damage) and serum glutathione peroxidase enzyme (GPX) as one of the antioxidant enzymes. Results: The highest respirable wood dust concentration was that generated by sawing operations. Laboratory investigations revealed statistically significantly higher frequency of CA which was associated with significant decrement in serum GPX among the exposed workers. Increased CA was positively correlated with the duration and the degree of exposure. Conclusion:
Occupational exposure to wood dust is associated with genotoxicity and oxidative stress. This could be due to lack of protective measures, so there is a need to educate the carpenters about the potential hazard of occupational exposure and the importance of using protective measures.
 
Keywords
Key Words: wood dust; DNA damage; chromosomal aberrations; Oxidative Stress; glutathione peroxidase
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