Samy, M., Abdallah, H., Ayoub, M., Vylegzhanina, M., Volkov, A., Sukhanova, T. (2020). Eco-Friendly Route for Encapsulation of 5-Fluorouracil Into Polycaprolactone Nanoparticles. test, 63(1), 255-267. doi: 10.21608/ejchem.2019.19380.2182
Moshera Samy; Heba M. Abdallah; Magdy M.H. Ayoub; M.E. Vylegzhanina; A.Ya. Volkov; T.E. Sukhanova. "Eco-Friendly Route for Encapsulation of 5-Fluorouracil Into Polycaprolactone Nanoparticles". test, 63, 1, 2020, 255-267. doi: 10.21608/ejchem.2019.19380.2182
Samy, M., Abdallah, H., Ayoub, M., Vylegzhanina, M., Volkov, A., Sukhanova, T. (2020). 'Eco-Friendly Route for Encapsulation of 5-Fluorouracil Into Polycaprolactone Nanoparticles', test, 63(1), pp. 255-267. doi: 10.21608/ejchem.2019.19380.2182
Samy, M., Abdallah, H., Ayoub, M., Vylegzhanina, M., Volkov, A., Sukhanova, T. Eco-Friendly Route for Encapsulation of 5-Fluorouracil Into Polycaprolactone Nanoparticles. test, 2020; 63(1): 255-267. doi: 10.21608/ejchem.2019.19380.2182

Eco-Friendly Route for Encapsulation of 5-Fluorouracil Into Polycaprolactone Nanoparticles

Egyptian Journal of Chemistry
Article 22, Volume 63, Issue 1, January 2020, Pages 255-267    PDF (1.67 M)
Document Type: Original Article
DOI: 10.21608/ejchem.2019.19380.2182
Authors
Moshera Samy* 1; Heba M. Abdallah2; Magdy M.H. Ayoub3; M.E. Vylegzhanina4; A.Ya. Volkov4; T.E. Sukhanova5
1polymers and pigments, national research center,Giza,Egypt
2polymers and pigments, national research center, Giza, Egypt
3Polymers and Pigments,National research center,Giza,Egypt
4Institute of Macromolecular Compounds, Russian Academy of Sciences, Russia
5Institute of Macromolecular Compounds and S.V. Lebedev Institute of Synthetic Rubber,Russia
Abstract
The main objective of this study was to allocate and evaluate the most optimum conditions to prepare the 5-Fluorouracil (5-FU) entrapped polycaprolactone (PCL) nanoparticles (5-FU–PCNs) by eco-friendly route. The inner aqueous phase (W1) was added to solution containing PCL with homogenization to form primary emulsion (W1/O) which was emulsified with the outer aqueous phase (W2) containing polyvinyl alcohol (PVA) as stabilizer to attain the double emulsion (W1/O/W2). The different parameters were investigated to reach the most successful formulation for 5-FU–PCNs, such as polymer concentration, effect of stabilizer concentration ratio (0.5%, 1% and 3%) on drug encapsulation efficiency, etc. The encapsulation efficiency of PCNs was in the range of 14-65.6%. The prepared nanoparticles showed the spherical shape having an average size of 183-944nm.The prepared systems were elucidated by fourier transform infrared spectroscopy (FTIR), UV-spectroscopy, photon correlation spectroscopy (PCS), X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA),scanning electron (SEM) and atomic-force microscopy (AFM).
The optimized ratios of the different parameters of double emulsion process were founded. SEM and AFM confirmed the complicated morphology and the formation of the spherical micro- and nanocapsules.
Keywords
Polycaprolactone, Nanoparticles, 5-Fluorouracil, Encapsulation Efficiency, Structure; Morphology, Thermal Characterization
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