Saleh, G., Askal, H., Abdelmageed, O., Refaat, I. (1994). SELECTIVE SPECTROPHOTOMETRIC METHODS FOR THE ANALYSIS OF D-PENICILLAMINE BULK DRUG AND CAPSULES IN THE PRESENCE OF SOME PENICILLINS AND THEIR DEGRADATION PRODUCTS. test, 17(1), 65-71. doi: 10.21608/bfsa.1994.69789
Gamal A. Saleh; Hassan F. Askal; Osama H. Abdelmageed; Ibrahim H. Refaat. "SELECTIVE SPECTROPHOTOMETRIC METHODS FOR THE ANALYSIS OF D-PENICILLAMINE BULK DRUG AND CAPSULES IN THE PRESENCE OF SOME PENICILLINS AND THEIR DEGRADATION PRODUCTS". test, 17, 1, 1994, 65-71. doi: 10.21608/bfsa.1994.69789
Saleh, G., Askal, H., Abdelmageed, O., Refaat, I. (1994). 'SELECTIVE SPECTROPHOTOMETRIC METHODS FOR THE ANALYSIS OF D-PENICILLAMINE BULK DRUG AND CAPSULES IN THE PRESENCE OF SOME PENICILLINS AND THEIR DEGRADATION PRODUCTS', test, 17(1), pp. 65-71. doi: 10.21608/bfsa.1994.69789
Saleh, G., Askal, H., Abdelmageed, O., Refaat, I. SELECTIVE SPECTROPHOTOMETRIC METHODS FOR THE ANALYSIS OF D-PENICILLAMINE BULK DRUG AND CAPSULES IN THE PRESENCE OF SOME PENICILLINS AND THEIR DEGRADATION PRODUCTS. test, 1994; 17(1): 65-71. doi: 10.21608/bfsa.1994.69789

SELECTIVE SPECTROPHOTOMETRIC METHODS FOR THE ANALYSIS OF D-PENICILLAMINE BULK DRUG AND CAPSULES IN THE PRESENCE OF SOME PENICILLINS AND THEIR DEGRADATION PRODUCTS

Bulletin of Pharmaceutical Sciences Assiut University
Article 7, Volume 17, Issue 1, July 1994, Pages 65-71    PDF (385.05 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1994.69789
Authors
Gamal A. Saleh; Hassan F. Askal; Osama H. Abdelmageed; Ibrahim H. Refaat
Department of Pharmaceutica1Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
Abstract
Three simple, rapid and sensitive spectrophotometric methods for the assay of D-penicillamine in the presence of some penicillin preparations as well as common penicillin degradation products were carried out. These methods are based on the oxidation of penicillamine with ferric  ion in aqueous solution. The indirect quantitation of the produced ferrous ions was carried out at 523, 690 and 510 nm for ferro-bipyridyl, ferro-ferricyanide and ferro-1,10-phenanthroline complexes respectively. All variables were studied to optimize the reaction conditions. Regression analysis of Beer's plot showed good correlation in a general concentration range of 1-10 mg D-penicillamine/ml. No interference could be observed from the presence of many structurally relevant compounds. In addition, common pharmaceutical adjuvants present incapsules did not interfere. The validity of the proposed methods was tested by analyzing artaminecapsules. Recoveries were 99.5 - 100.9%.
Statistics
Article View: 91
PDF Download: 77