Abdel-Kreem, M., El-Semary, M., Eshba, N., Shafik, R. (1994). NOVEL STRUCTURAL HYBRIDS OF MESCALINE WITH PCP-ANALOGS: POTENTIAL ANTAGONISTS FOR CENTRAL PCP-RECEPTORS. test, 17(2), 105-112. doi: 10.21608/bfsa.1994.69795
M. F. M. Abdel-Kreem; M. M. El-Semary; N. H. Eshba; R. M. Shafik. "NOVEL STRUCTURAL HYBRIDS OF MESCALINE WITH PCP-ANALOGS: POTENTIAL ANTAGONISTS FOR CENTRAL PCP-RECEPTORS". test, 17, 2, 1994, 105-112. doi: 10.21608/bfsa.1994.69795
Abdel-Kreem, M., El-Semary, M., Eshba, N., Shafik, R. (1994). 'NOVEL STRUCTURAL HYBRIDS OF MESCALINE WITH PCP-ANALOGS: POTENTIAL ANTAGONISTS FOR CENTRAL PCP-RECEPTORS', test, 17(2), pp. 105-112. doi: 10.21608/bfsa.1994.69795
Abdel-Kreem, M., El-Semary, M., Eshba, N., Shafik, R. NOVEL STRUCTURAL HYBRIDS OF MESCALINE WITH PCP-ANALOGS: POTENTIAL ANTAGONISTS FOR CENTRAL PCP-RECEPTORS. test, 1994; 17(2): 105-112. doi: 10.21608/bfsa.1994.69795

NOVEL STRUCTURAL HYBRIDS OF MESCALINE WITH PCP-ANALOGS: POTENTIAL ANTAGONISTS FOR CENTRAL PCP-RECEPTORS

Bulletin of Pharmaceutical Sciences Assiut University
Article 2, Volume 17, Issue 2, December 1994, Pages 105-112    PDF (421.82 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1994.69795
Authors
M. F. M. Abdel-Kreem; M. M. El-Semary; N. H. Eshba; R. M. Shafik
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
Abstract
The possible involvement of the synclinal conformation of mescaline with phencyclidine (PCP)-receptors has promoted the synthesis of certain novel structural hybrids of mescaline with PCP-analogs.
The effect of mescaline and the potential antagonisticactivity of the newly proposed derivatives at central PCP-receptors of albino rat brains will await investigation.
The suggested compounds were chemically 1-aryl-1-(3,4,5-trimethoxy; or trihydroxy) phenethylamino; or N-substituted-phenethylamino cycloalkanes. An N-(2-chloroethyl) moiety was, also incorporated into some of the designed analogs for exploration of the possible participation of such alkylating arm to the elicited activity.
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