Habeeb, A., Mabrouk, M. (1993). FLUOROMETRIC•DETERMINATION OF ACYCLOVIR IN SPIKED HUMAN PLASMA. test, 16(1), 106-111. doi: 10.21608/bfsa.1993.70034
A. A. Habeeb; M. M. Mabrouk. "FLUOROMETRIC•DETERMINATION OF ACYCLOVIR IN SPIKED HUMAN PLASMA". test, 16, 1, 1993, 106-111. doi: 10.21608/bfsa.1993.70034
Habeeb, A., Mabrouk, M. (1993). 'FLUOROMETRIC•DETERMINATION OF ACYCLOVIR IN SPIKED HUMAN PLASMA', test, 16(1), pp. 106-111. doi: 10.21608/bfsa.1993.70034
Habeeb, A., Mabrouk, M. FLUOROMETRIC•DETERMINATION OF ACYCLOVIR IN SPIKED HUMAN PLASMA. test, 1993; 16(1): 106-111. doi: 10.21608/bfsa.1993.70034

FLUOROMETRIC•DETERMINATION OF ACYCLOVIR IN SPIKED HUMAN PLASMA

Bulletin of Pharmaceutical Sciences Assiut University
Article 11, Volume 16, Issue 1, June 1993, Pages 106-111    PDF (681.11 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1993.70034
Authors
A. A. Habeeb; M. M. Mabrouk
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt
Abstract
A highly sensitive fluorometric method for determination of acyclovir  is described. The method depends  on the interaction between acyclovir .and 7-hydroxy-4-methylcoumarin where a fluorophore of high fluorogenic activity is formed which has wavelengths of maximum excitation and emission of 342 and 452,respectively. The method is used for determination of acyclovir in human plasma in the range of 5-10 ngm-1 in a rectilinear relationship. The mean percentage recovery was 99.954 S.D. ± 1.450 in case of bulk drug while it was 99.893 S.D.+ 0.711 in case of 6 concentrations of human plasma. The method is recommended for drug monitoring of acyclovir.
Statistics
Article View: 93
PDF Download: 172