IMPROVED DELIVERY THROUGH BIOLOGICAL MEMBRANES: PREPARATION AND INVESTIGATION OF STABLE DOPAMINE CHEMICAL DELIVERY SYSTEM SAMPLES | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 9, Volume 16, Issue 2, December 1993, Pages 175-182 PDF (519.37 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1993.70205 | ||
| Authors | ||
| Nicholas Bodor1; Hassan H. Farag2; Farghaly A. Omar2 | ||
| 1Center for Drug Discovery, College of Pharmacy, J. Hillis Miller Health Center, University of Florida, Gainesville, Florida 32610 | ||
| 2Department of Medicinal Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
| Abstract | ||
| Crystalline dopamine chemical delivery system and its cyclodextrin complex could be prepared. The crystalline compound showed better stability at different storage conditions. The iv injection of aqueous solutions of the complex showed higher brain delivery than the DMSO solution of the pure compound. The ip Injection of the aqueous solution of the complex delivered good concentration of the deacylated dopamine quaternary (dopamine prodrug-moiety) to the brain. | ||
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