Abdel Rahman, A., Aboutaleb, A., Stamm, A., Abdel Rahman, S., Samy, E. (1992). EFFECT OF CELLULOSIC POLYMERS ON THE PHYSICAL PROPERTIES AND DISSOLUTION OF IBUPROFEN GRANULES. test, 15(1), 89-99. doi: 10.21608/bfsa.1992.70219
Aly A. Abdel Rahman; A. E. Aboutaleb; A. Stamm; S. I. Abdel Rahman; E. M. Samy. "EFFECT OF CELLULOSIC POLYMERS ON THE PHYSICAL PROPERTIES AND DISSOLUTION OF IBUPROFEN GRANULES". test, 15, 1, 1992, 89-99. doi: 10.21608/bfsa.1992.70219
Abdel Rahman, A., Aboutaleb, A., Stamm, A., Abdel Rahman, S., Samy, E. (1992). 'EFFECT OF CELLULOSIC POLYMERS ON THE PHYSICAL PROPERTIES AND DISSOLUTION OF IBUPROFEN GRANULES', test, 15(1), pp. 89-99. doi: 10.21608/bfsa.1992.70219
Abdel Rahman, A., Aboutaleb, A., Stamm, A., Abdel Rahman, S., Samy, E. EFFECT OF CELLULOSIC POLYMERS ON THE PHYSICAL PROPERTIES AND DISSOLUTION OF IBUPROFEN GRANULES. test, 1992; 15(1): 89-99. doi: 10.21608/bfsa.1992.70219

EFFECT OF CELLULOSIC POLYMERS ON THE PHYSICAL PROPERTIES AND DISSOLUTION OF IBUPROFEN GRANULES

Bulletin of Pharmaceutical Sciences Assiut University
Article 10, Volume 15, Issue 1, 1992, Pages 89-99    PDF (496.55 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1992.70219
Authors
Aly A. Abdel Rahman1; A. E. Aboutaleb1; A. Stamm2; S. I. Abdel Rahman1; E. M. Samy1
1Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
2Faculty of Pharmacy, Louis Pasteur University, France
Abstract
Ibuprofen sustained release granules were prepared using ce11ulosic polymers including, ethy1cel1u1ose 20, hydroxypropyl methyl cellulose (Pharmacoat 606) and hydroxypropyl methy1 cellulose phthalate (HP 55 F). Polyvinyl pyrro1idone (PVP) was used also as a granu1ating agent for comparison.
Increasing the concentration of the granulating agents investigated lead to retardation of the drug release rate except for Pharmacoat 606. Ethyl cellulose 20 in 5% w/v concentration proved to be the best retardant for ibuprofen release rate from the prepared granules.
The physical properties of ibuprofen powder, ibuprofen granules as a control and ibuprofen granules granulated with 5% w/v ethyl cellulose 20 were examined and including the size range, the angle of repose, the flow rate, the bulk density, the Hausner factor, the compressibi1ity, the friability and the parameters of Kawakita.
The effect of particle size of ibuprofen granules prepared by 5% w/v ethyl cellulose 20 as a granulating agent was checked. Increasing the particle size of the prepared granules lead to more prolongation in ibuprofen release rate.
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