EFFECT OF SUSPENDING AGENTS ON THE DISSOLUTION AND BIOAVAILABILITY OF AMPICILLIN | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 2, Volume 14, Issue 1, 1991, Pages 6-12 PDF (384.97 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.1991.70370 | ||
| Authors | ||
| A. A. Bosela; M. S. Treki; M. A. Mahdy; M. S. Mohamed | ||
| Department of Pharmaceutics, Al-Fateh University, Tripoli, Libya | ||
| Abstract | ||
| The effect of various suspending agents viz., Methyl cellulose, Sodium carboxymethyl cellulose, Bentonite and polyvinylpyrrolidone on the dissolution of ampicillin from its suspensions was studied. Methyl cellulose (MC) gave the best ampicillin suspensions as indicated by the highest sedimentation volume (F=0.78) while polyvinylpyrrolidone (PVP) gave the poorest suspensions (F=0.11). The effectiveness of the suspending agents decreased in the following order: MC > Bentonite > Sod. CMC > PVP. The in-vitro dissolution studies showed that all the suspending agents decreased the dissolution rate of the drug. As the suspending agents concentration was increased, the retardation effect on drug dissolution increased. The bioavailability of ampicillin from its suspensions was studied in 6 healthy volunteers by urinary excretion method. Commercial product (Penbritin) was included for comparison. Both % dose excreted and maximum excretion rate were markedly reduced except' in suspension containing Sod. CMC. However, the time for maximum excretion was not affected. | ||
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